{"id":6533,"date":"2021-09-28T03:21:40","date_gmt":"2021-09-27T19:21:40","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6533"},"modified":"2021-09-28T03:21:40","modified_gmt":"2021-09-27T19:21:40","slug":"s-news-introduction-of-a-new-synthetic-route-about-330792-70-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6533","title":{"rendered":"S News Introduction of a new synthetic route about 330792-70-6"},"content":{"rendered":"

330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile<\/a><\/p>\n

[0383] A mixture of 5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile (1.0 g, 3.6mmol), ethyl2-(l-benzylpiperidin-4-ylidene)acetate (1.1 g, 4.3 mmol) and K2C03 (745 mg, 5.4mmol) in DMF (20 mL) was heated to 80 \u00b0C for 16 hr under N2? The reaction was quenchedwith water (20 mL) and extracted with EA (20 mL x 3). The combined organic layers were driedover Na2S04, concentrated and purified by chromatography column on silica gel using 30percent ofEA in PEas eluant to give the product (950 mg, 54.9percent) as a yellow solid. 1H NMR (400 MHz,DMSO-d6) 8 11.92 (s, 1H), 7.84 (d, J = 8.8 Hz, 2H), 7.48-7.40 (m, 2H), 7.36-7.29 (m, 4H), 7.27-7.23 (m, 1H), 7.20 (t, J = 7.6 Hz, 1H), 7.15-7.07 (m, 4H), 3.55 (s, 2H), 3.01 (s, 2H), 2.81-2.73(m, 2H), 2.39-2.27 (m, 2H), 2.26-2.16 (m, 2H), 1.83-1.74 (m, 2H). MS (ESI, m\/e) [M+1t 489.9.<\/p>\n

The synthetic route of 330792-70-6 has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; GUO, Yunhang; BEIGENE, LTD.; WANG, Zhiwei; WO2014\/173289; (2014); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 330792-70-6 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[192,131],"tags":[127],"class_list":["post-6533","post","type-post","status-publish","format-standard","hentry","category-330792-70-6","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nIntroduction of a new synthetic route about<\/title>\n<meta name=\"description\" content=\"330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 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