{"id":6531,"date":"2021-09-28T03:21:40","date_gmt":"2021-09-27T19:21:40","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6531"},"modified":"2021-09-28T03:21:40","modified_gmt":"2021-09-27T19:21:40","slug":"28-sep-2021-news-a-new-synthetic-route-of-33064-36-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6531","title":{"rendered":"28-Sep-2021 News A new synthetic route of 33064-36-7"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 33064-36-7, name is 1H-Pyrazole-3-carboxamide, A new synthetic method of this compound is introduced below., Application In Synthesis of 1H-Pyrazole-3-carboxamide<\/a><\/p>\n

A mixture of feri-butyl 4-(10-bromo-2-oxo-l,2-dihydropyrimido[l,2-b]indazol-4-yl)piperidine-l- carboxylate (200 mg, 0.45 mmol), lH-pyrazole-3-carboxamide (124 mg, 1.12 mmol), tripotassium phosphate (133 mg, 0.63 mmol), [(2-di-ieri-butylphosphino-3,6-dimethoxy-2′,4′,6′-triisopropyl-l, – biphenyl)-2-(2 ‘-amino- l,l’-biphenyl)]palladium(II) methanesulfonate (= tBuBrettPhos Pd G3) (23 mg, 0.027 mmol), 2-(di-ieri-butylphosphino)-2′,4′,6′- triisopropyl-3,6-dimethoxy-l,l ‘-biphenyl (= tBuBrettPhos) (13 mg, 0.027 mmol) was added to a flask and flushed with argon before being suspended in 2 ml of ieri-butanol. Argon was bubbled for Imin more through the suspension, which was then stirred overnight at 110 C. After cooling to RT, the mixture was filtered and purified by preparative HPLC (gradient acetonitrile\/water with 0.1 % trifluoroacetic acid). Evaporation of the combined product fractions yielded the title compound (119 mg, 56% of theory). LC-MS (Method 2): Rt = 2.73 min, MS (ESINeg): m\/z = 476 [M-H]”<\/p>\n

The synthetic route of 33064-36-7 has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; ELLERMANN, Manuel; VALOT, Gaelle; CANCHO GRANDE, Yolanda; HASSFELD, Jorma; KINZEL, Tom; KOeBBERLING, Johannes; BEYER, Kristin; ROeHRIG, Susanne; SPERZEL, Michael; STAMPFUSS, Jan; MEYER, Imke; KOeLLNBERGER, Maria; BURKHARDT, Nils; SCHLEMMER, Karl-Heinz; STEGMANN, Christian; SCHUHMACHER, Joachim; WERNER, Matthias; (308 pag.)WO2016\/173948; (2016); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 33064-36-7 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[287,131],"tags":[126],"class_list":["post-6531","post","type-post","status-publish","format-standard","hentry","category-33064-36-7","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nA new synthetic route of<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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