{"id":6509,"date":"2021-09-27T03:19:38","date_gmt":"2021-09-26T19:19:38","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6509"},"modified":"2021-09-27T03:19:38","modified_gmt":"2021-09-26T19:19:38","slug":"s-21-news-some-tips-on-18048-64-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6509","title":{"rendered":"S-21 News Some tips on 18048-64-1"},"content":{"rendered":"

Related Products of 18048-64-1<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 18048-64-1 as follows.<\/p>\n

5- (2-hydroxy-3-amino-5,6,7,8-tetrahydronaphthalen-2-yl) – furan-2-carboxylic acid(1.0g, 3.66m mol), dissolved in 40ml 1mol \/ l of HCl solution, cooled to0 , thereto was slowly added dropwise of NaNO2(303 mg of the, 4.39m mol) in 40ml aqueoussolution; BI dropwise, maintaining the reaction temperature of the reaction was continued for 30min, TLC trace starting material 5- (2-hydroxy – 3-amino-5,6,7,8-tetrahydronaphthalen-2-yl) -furan-2-carboxylic acid.Was added1- (3,4-dimethylphenyl) methyl-1H-pyrrol-5 (4 hydrogen) -one (740 mg of, -3-3.66m mol), adjusted pH with saturated sodium bicarbonate solution after 15min about 8, was added40ml of absolute ethanol, the reaction naturally to room temperature.24h after LC-MS testing of raw materials reactionwas complete.Filtered, the filter cake washed with water to prepare a suspension adjust PH around 5, and then filtered, the filter cake after dryingcolumn chromatography to obtain the target product (Z) -5- (3- (2- (1- (3,4-dimethyl phenyl) -3-methyl-5-oxo-1,5-dihydro – pyrazol-4-ylidene) hydrazino) -2-hydroxy-5,6,7,8-tetrahydronaphthalene -1 -yl) – furan-2-carboxylic acid (compound 18) (192mg, 10.8% yield).<\/p>\n

According to the analysis of related databases, 18048-64-1, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; Qilu Pharmaceutical Co., Ltd; Wang, Jingyi; Fan, Chuanwen; Zhang, Long; Yan, Shousheng; Zhang, Soming; Zhao, Hongbing; Zhou, Haojie; Yang, Chuanwei; Zhao, Hongling; Yang, Yingying; (46 pag.)CN103360317; (2016); B;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 18048-64-1, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[158,131],"tags":[127],"class_list":["post-6509","post","type-post","status-publish","format-standard","hentry","category-18048-64-1","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nSome tips on<\/title>\n<meta name=\"description\" content=\"Related Products of 18048-64-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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