{"id":6505,"date":"2021-09-27T03:19:38","date_gmt":"2021-09-26T19:19:38","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6505"},"modified":"2021-09-27T03:19:38","modified_gmt":"2021-09-26T19:19:38","slug":"sep-21-news-discovery-of-16078-71-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6505","title":{"rendered":"Sep-21 News Discovery of 16078-71-0"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 16078-71-0, name is Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16078-71-0, Recommanded Product: Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate<\/a><\/p>\n

A mixture of 1.50 g (6 mmol) of ethyl 5-amine-1-phenyl-1Hpyrazole-4-carboxylate (13) and 20 mL of 85% phosphoric acidwas maintained under reflux and stirring for 6 h at 170 C. Aftercompletion of the reaction, 50 mL of crushed ice was added, andthen the mixture was basified to pH 7 with NaOH (6 M aq). Themixture was extracted with dichloromethane (3 30 mL). Thecombined organic solution was washed with water (3 50 mL),dried (anhydrous sodium sulfate), filtered, and concentrated undervacuum to afford 14 as a brown oil.Yield: 86%. IR (KBr. cm1): 3418-3182; 1618; 1597; 1550;760-694. 1H NMR (400 MHz, CDCl3, TMS, d in ppm): 3.84 (s, 2H,NH2); 5.61 (d, 1H, J = 2.0 Hz, H4); 7.42 (d, 1H, J = 1.8 Hz, H3);7.57-7.32 (m, 5H, H20, H30, H40, H50, H60). 13C NMR (100 MHz,CDCl3, TMS, d in ppm): 90.6; 123.9; 127.4; 129.4; 138.6; 140.3;144.7. EI [M1] 157.8.<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.<\/p>\n

Reference:
Article; Silva, Thais B.; Bernardino, Alice M.R.; Ferreira, Maria de Lourdes G.; Rogerio, Kamilla R.; Carvalho, Leonardo J.M.; Boechat, Nubia; Pinheiro, Luiz C.S.; Bioorganic and Medicinal Chemistry; vol. 24; 18; (2016); p. 4492 – 4498;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[263,131],"tags":[127],"class_list":["post-6505","post","type-post","status-publish","format-standard","hentry","category-16078-71-0","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nDiscovery of<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 16078-71-0, name is Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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