{"id":6490,"date":"2021-09-26T03:44:09","date_gmt":"2021-09-25T19:44:09","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6490"},"modified":"2021-09-26T03:44:09","modified_gmt":"2021-09-25T19:44:09","slug":"9-26-2021-news-simple-exploration-of-3469-69-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6490","title":{"rendered":"9\/26\/2021 News Simple exploration of 3469-69-0"},"content":{"rendered":"<p>Adding a certain compound to certain chemical reactions, such as: 3469-69-0, name is 4-Iodopyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound  3469-69-0, <a href=\"https:\/\/www.ambeed.com\/products\/3469-69-0.html\">HPLC of Formula: C3H3IN2<\/a><\/p>\n<p>To a mixture of 4-iodo-1H-pyrazole (2.91 g, 15 mmol), Pd(PPh3)2C12 (1 g, 1.5 mmol), CuT (286 mg, 1.5 mmol) and Et3N (6 mL) in EtOH (20 mL) was added trimethylsilylacetylene (3.2 mL, 22.5 mmol). The reaction was stirred at 70C for 4 h, then cooled to rt and concentratedvacuo. The residue was diluted with EtOAc (20 mL) and the undissolved solid was removed by filtration. The filtrate was dried over Na2504 and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE\/EtOAc (v\/v) = 5\/1) to give the title compound as a white solid (1.3 g, 53%).LC-MS (ESI, pos. ion) m\/z: 165 [M + H]1H NMR (400 MHz, CDC13) 5 (ppm): 0.24 (s, 9H), 7.76 (s, 2H), 11.43 (br, 1H).<\/p>\n<p>In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodopyrazole, other downstream synthetic routes, hurry up and to see.<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.carres.2011.03.026\">Patent; XI, Ning; SUNSHINE LAKE PHARMA CO., LTD.; YIN, Lihua; LI, Xiaobo; YU, Na; WU, Yanjun; WO2013\/177092; (2013); A1;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodopyrazole, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[134,131],"tags":[126],"class_list":["post-6490","post","type-post","status-publish","format-standard","hentry","category-3469-69-0","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Simple exploration of<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 3469-69-0, name is 4-Iodopyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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