{"id":6449,"date":"2021-09-23T03:34:37","date_gmt":"2021-09-22T19:34:37","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6449"},"modified":"2021-09-23T03:34:37","modified_gmt":"2021-09-22T19:34:37","slug":"9-23-2021-news-brief-introduction-of-141573-95-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6449","title":{"rendered":"9\/23\/2021 News Brief introduction of 141573-95-7"},"content":{"rendered":"

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 141573-95-7 as follows. Computed Properties of C8H10F2N2O2<\/a><\/p>\n

Preparation Example V.13-difluoromethyl-1-methyl-1H-pyrazol-4-ylcarboxylic acidA mixture of ethyl 3-difluoromethyl-1-methyl-1H-pyrazol-4-ylcarboxylate (1.4 g, 52 mmol) and aqueous sodium hydroxide solution (10% strength, 3.1 g, 8 mmol) was stirred at 60 C. for 2 h. The reaction mixture was cooled to room temperature, and the pH was then adjusted to 1 using concentrated hydrochloric acid. The reaction mixture was cooled further to 0 C., resulting in the precipitation of a solid. The precipitated solid was filtered off, washed with cyclohexane and dried under reduced pressure. This gave 3-difluoromethyl-1-methyl-1H-pyrazol-4-ylcarboxylic acid as a solid (amount: 0.8 g; yield: 87%). 1H-NMR (DMSO-d6): delta=3.9 (s, 2H), 7.2 (t, 1H), 8.35 ppm (s, 1H).<\/p>\n

According to the analysis of related databases, 141573-95-7, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; BASF SE; US2011\/40096; (2011); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 141573-95-7, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[187,131],"tags":[127],"class_list":["post-6449","post","type-post","status-publish","format-standard","hentry","category-141573-95-7","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nBrief introduction of<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 141573-95-7 as follows. 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