{"id":6443,"date":"2021-09-23T03:34:37","date_gmt":"2021-09-22T19:34:37","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6443"},"modified":"2021-09-23T03:34:37","modified_gmt":"2021-09-22T19:34:37","slug":"23-sep-news-extended-knowledge-of-158001-28-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6443","title":{"rendered":"23-Sep News Extended knowledge of 158001-28-6"},"content":{"rendered":"<p><a href=\"https:\/\/www.ambeed.com\/products\/158001-28-6.html\">Reference of 158001-28-6<\/a>,Some common heterocyclic compound, 158001-28-6, name is 5-Amino-1-(tert-butyl)-1H-pyrazole-4-carbonitrile, molecular formula is C8H12N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n<p>A mixture of 5-amino-1-(tert-butyl)-1H-pyrazole-4-carbonitrile (8, 1.1 g, 6.7 mmol) in formamide (15 ml) under a nitrogen atmosphere was heated in a microwave at 180 C for 30 min. The mixture was extracted with EtOAc (3 x 30 ml) and the organic layer was washed successively with sodium carbonate (30 ml), water (30 ml) and brine (30 ml). The organic layer was dried with magnesium sulfate, filtered and concentrated via evaporation of the solvent under a reduced pressure. The product was isolated as a brown solid in 77 % yield (0.97 g, 5.1 mmol). 1H NMR (200 MHz, CDCl3) delta 8.31 (s, 1 H), 7.85 (s, 1 H), 6.17 (s, 2 H), 1.77 (s, 9 H); 13C NMR (50 MHz, CDCl3) delta 157.9, 154.4, 153.2, 128.9, 102.1, 60.4, 29.2; HRMS (CI) calcd for C9H13N5 (M) 191.1171, found 191.1180.<\/p>\n<p>These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-1-(tert-butyl)-1H-pyrazole-4-carbonitrile, its application will become more common.<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/doi.org\/10.1039\/c6md00675b\">Article; Todorovic, Nick; Awuah, Emelia; Shakya, Tushar; Wright, Gerard D.; Capretta, Alfredo; Tetrahedron Letters; vol. 52; 44; (2011); p. 5761 &#8211; 5763;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-1-(tert-butyl)-1H-pyrazole-4-carbonitrile, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[317,131],"tags":[126],"class_list":["post-6443","post","type-post","status-publish","format-standard","hentry","category-158001-28-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Extended knowledge of<\/title>\n<meta name=\"description\" content=\"Reference of 158001-28-6,Some common heterocyclic compound, 158001-28-6, name is 5-Amino-1-(tert-butyl)-1H-pyrazole-4-carbonitrile, molecular formula is C8H12N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=6443\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Extended knowledge of\" \/>\n<meta property=\"og:description\" content=\"Reference of 158001-28-6,Some common heterocyclic compound, 158001-28-6, name is 5-Amino-1-(tert-butyl)-1H-pyrazole-4-carbonitrile, molecular formula is C8H12N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=6443\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-09-22T19:34:37+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=6443\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=6443\",\"name\":\"Extended knowledge of\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-09-22T19:34:37+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Reference of 158001-28-6,Some common heterocyclic compound, 158001-28-6, name is 5-Amino-1-(tert-butyl)-1H-pyrazole-4-carbonitrile, molecular formula is C8H12N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=6443#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=6443\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=6443#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"23-Sep News Extended knowledge of 158001-28-6\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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