{"id":6410,"date":"2021-09-18T05:53:13","date_gmt":"2021-09-17T21:53:13","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6410"},"modified":"2021-09-18T05:53:13","modified_gmt":"2021-09-17T21:53:13","slug":"s-21-news-the-important-role-of-131797-35-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6410","title":{"rendered":"S-21 News The important role of 131797-35-8"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 131797-35-8, name is 5-Chloro-3-(trifluoromethyl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 131797-35-8, Product Details of 131797-35-8<\/a><\/p>\n

To a solution of 2-chloro-7-(chloromethyl)-N-ethyl-5-oxo-5H-[l,3]thiazolo[3,2-a]pyrimidine- 3-carboxamide (2 g, 6.53 mmol) in acetonitrile (10 mL) was added 5-chloro-3-(trifluoromethyl)-lH- pyrazole (872 mg, 5.11 mmol), potassium iodide (542 mg, 3.26 mmol), and potassium carbonate (1.8 g, 13 mmol). The resulting mixture was stirred for 1 h at 80 C and concentrated in vacuo. The residue was purified by flash chromatography on silica gel eluting with ethyl acetate\/petroleum ether (1\/1) to afford of 2-chloro-7-[[5-chloro-3-(trifluoromethyl)-lH-pyrazol-l-yl]methyl]-N-ethyl-5-oxo-5H- [l,3]thiazolo[3,2-a]pyrimidine-3-carboxamide (1.1 g, 38%) as a yellow solid. LCMS (ESI): M+H + = 441.0.<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Chloro-3-(trifluoromethyl)-1H-pyrazole, and friends who are interested can also refer to it.<\/p>\n

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; YU, Jiang; WU, Guosheng; YUEN, Po-Wai; VILLEMURE, Elisia; SCHWARZ, Jacob; LY, Cuong; SELLERS, Benjamin; VOLGRAF, Matthew; WO2015\/52226; (2015); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Chloro-3-(trifluoromethyl)-1H-pyrazole, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[220,131],"tags":[126],"class_list":["post-6410","post","type-post","status-publish","format-standard","hentry","category-131797-35-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 131797-35-8, name is 5-Chloro-3-(trifluoromethyl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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