{"id":6402,"date":"2021-09-18T05:53:13","date_gmt":"2021-09-17T21:53:13","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6402"},"modified":"2021-09-18T05:53:13","modified_gmt":"2021-09-17T21:53:13","slug":"18-sep-2021-news-extended-knowledge-of-187998-35-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6402","title":{"rendered":"18-Sep-2021 News Extended knowledge of 187998-35-2"},"content":{"rendered":"

These common heterocyclic compound, 187998-35-2, name is 1-(4-Chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C11H9ClN2O2<\/a><\/p>\n

(3) Reference Example 1 [(trifluoromethyl) pyridin-5-yl] (3) 5-methyl-1 in -1H- pyrazole-4-carboxylic acid in place of Reference Example 6 in 1 – (4-chlorophenyl) -5-methyl -1H- pyrazole-4-carboxylic acid, the reaction process using the same acid under ice-cooling and the reaction mixture (281mg) by 1- (5-amino-3-cyano It was added to a pyridine solution of the no-2-yl) -4-cyano nopi piperidine (228mg) and, after stirring 0.25 hours at the same temperature, tri ethyl amine was added, was stirred at room temperature for 2 hours. After the reaction, water was added, and the precipitated solid was collected and then filtered, washed by suspension to give the title compound (425mg) as a white solid<\/p>\n

The synthetic route of 1-(4-Chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; Watanabe, Masayuki; Furukawa, Hiroyuki; Hamada, Maiko; Fuji, Naoto; Ushio, Hiroyuki; Takashima, Toru; (81 pag.)KR2015\/2661; (2015); A;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 1-(4-Chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[474,131],"tags":[127],"class_list":["post-6402","post","type-post","status-publish","format-standard","hentry","category-187998-35-2","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nExtended knowledge of<\/title>\n<meta name=\"description\" content=\"These common heterocyclic compound, 187998-35-2, name is 1-(4-Chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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