{"id":6390,"date":"2021-09-17T03:39:50","date_gmt":"2021-09-16T19:39:50","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6390"},"modified":"2021-09-17T03:39:50","modified_gmt":"2021-09-16T19:39:50","slug":"17-sep-2021-news-research-on-new-synthetic-routes-about-127107-23-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6390","title":{"rendered":"17-Sep-2021 News Research on new synthetic routes about 127107-23-7"},"content":{"rendered":"

Electric Literature of 127107-23-7<\/a>, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, This compound has unique chemical properties. The synthetic route is as follows.<\/p>\n

In a pressure tube, l-methylpyrazol-4-amine HCI (21 mg, 0.16 mmol), (S,2S)-2-(6-((2- bromo pyridin-4-yl)methoxy)-4-methoxybenzo[cf|thiazol-2-ylamino) cyclohexanol (60 mg, 0.13 mmol), RuPhos Pd G4 (11 mg, 0.013 mmol), RuPhos (6 mg, 0.013 mmol) and Cs2C03 (127 mg, 0.39 mmol) were dissolved in 1,4-dioxane (2 mL). The tube was sealed and purged with N2. The reaction mixture was stirred at 85C for 3h. LCMS monitored the reaction. The mixture was filtered and purified by mass-triggered preparative HPLC (Mobile phase: A = 10M NH4HCO3\/H2O, B = MeCN; Gradient: B = 30-60%; 10.0 min; Column: C18) to give (15′,25)-2-(4-methoxy-6-((2-(l-methyl-lH-pyrazol-4-ylamino)pyridin-4-yl) (1492) methoxy)benzo[cf|thiazol-2-ylamino)cyclohexanol (5 mg, 9%) as a white solid. MS (ES+) C24H28N603S requires: 480, found: 481 [M+H]+. NMR (500MHz, DMSO) delta 8.81 (s, 1H), 8.07 (d, J = 5.3 Hz, 1H), 7.91 (s, 1H), 7.61 (d, J = 7.5 Hz, 1H), 7.37 (s, 1H), 6.91 (d, J = 2.3 Hz, 1H), 6.70 (s, 1H), 6.65 (d, J= 5.3 Hz, 1H), 6.54 (d, J = 2.2 Hz, 1H), 5.02 (s, 2H), 4.77 (d, J = 5.0 Hz, 1H), 3.83 (s, 3H), 3.79 (s, 3H), 3.51 (s, 1H), 2.02 (s, 1H), 1.87 (d, J = 11.2 Hz, 1H), 1.63 (t, J= 10.8 Hz, 2H), 1.23 (s, 5H).<\/p>\n

The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-pyrazol-4-amine hydrochloride. I believe this compound will play a more active role in future production and life.<\/p>\n

Reference:
Patent; TESARO, INC.; JONES, Philip; CZAKO, Barbara; BURKE, Jason P.; CROSS, Jason; LEONARD, Paul Graham; TREMBLAY, Martin; MANDAL, Pijus; (232 pag.)WO2018\/119387; (2018); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-pyrazol-4-amine hydrochloride. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298,131],"tags":[126],"class_list":["post-6390","post","type-post","status-publish","format-standard","hentry","category-127107-23-7","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nResearch on new synthetic routes about<\/title>\n<meta name=\"description\" content=\"Electric Literature of 127107-23-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, This compound has unique chemical properties. 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