{"id":6355,"date":"2021-09-16T03:54:17","date_gmt":"2021-09-15T19:54:17","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6355"},"modified":"2021-09-16T03:54:17","modified_gmt":"2021-09-15T19:54:17","slug":"16-sep-2021-news-extracurricular-laboratory-synthetic-route-of-2458-26-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6355","title":{"rendered":"16-Sep-2021 News Extracurricular laboratory: Synthetic route of 2458-26-6"},"content":{"rendered":"

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2458-26-6 as follows. Recommanded Product: 2458-26-6<\/a><\/p>\n

Aromatic substrate 1b (0.1mmol), 3-phenylpyrazole 2m (0.15mmol), cuprous bromide (0.1mmol), potassium acetate (0.2mmol), DMSO (1.0mL) were added to the 15mL Schlenk tube, then directly sealed tube at 85 C for 12h. After the reaction was completed, the mixture was cooled to room temperature, and a small amount of ethyl acetate and ammonia were added to quench the reaction. The ethyl acetate was repeatedly extracted. The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate, filtered under reduced pressure, and the solvent was evaporated under reduced pressure. The crude product was separated and purified by a preparative plate (DCM: MeOH = 35: 1) to obtain 3bm as a white solid, 29.4 mg, with a yield of 70%.<\/p>\n

According to the analysis of related databases, 2458-26-6, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; Shanghai Laishi Blood Goods Co., Ltd.; Wang Peng; Yu Jinfeng; Li Jianjun; (32 pag.)CN110386929; (2019); A;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 2458-26-6, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[164,131],"tags":[126],"class_list":["post-6355","post","type-post","status-publish","format-standard","hentry","category-2458-26-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nExtracurricular laboratory: Synthetic route of<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2458-26-6 as follows. 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