{"id":6302,"date":"2021-09-13T03:20:12","date_gmt":"2021-09-12T19:20:12","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6302"},"modified":"2021-09-13T03:20:12","modified_gmt":"2021-09-12T19:20:12","slug":"9-13-21-news-extended-knowledge-of-16034-48-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6302","title":{"rendered":"9\/13\/21 News Extended knowledge of 16034-48-3"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16034-48-3, name is 1-Pyrazoleacetic Acid, A new synthetic method of this compound is introduced below., Computed Properties of C5H6N2O2<\/a><\/p>\n

70 mg (0.19 mmol) of 3-amino-4-(cyclopropyloxy)-N-[6-(2-fluorophenyl)pyridin-3-yl]benzamide (intermediate 116), 29.2 mg (0.23 mmol) of IH-pyrazol-l-ylacetic acid, 130.3 mg (0.25 mmol) of PYBOP and 101 mu (0.58 mmol) of N-ethyl-N-isopropylpropan-2-amine in 3.5 mL of anh DMF were stirred for 5 h at 50 C. The reaction mixture was concentrated and purified by HPLC (Waters Autopurificationsystem SQD; column: YMC-Triart C18 5mu 100x30mm; eluent A: water + 0.1% vol. formic acid (99%), eluent B: acetonitrile; gradient: 0-0.50 min 24% B, 25 mL\/min; 0.51-5.5 min 48- 66% B, 70 mL\/min; temperature: room temperature) to yield 33 mg (36%) of the title compound. 1H-NM (300 MHz, DMSO-d6): delta [ppm]= 0.70 – 0.78 (m, 2H), 0.83 – 0.91 (m, 2H), 4.01 – 4.09 (m, IH), 5.13 (s, 2H), 6.33 (t, IH), 7.27 – 7.37 (m, 2H), 7.41 – 7.50 (m, 2H), 7.55 (d, IH), 7.76 – 7.86 (m, 3H), 7.90 – 7.99 (m, IH), 8.25 – 8.31 (m, IH), 8.62 (d, IH), 9.03 (d, IH), 9.26 (s, IH), 10.48 (s, IH). LC-MS (Method 3): Rt = 1.20 min; MS (ESIpos): m\/z = 472 [M+H]+.<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; THEDE, Kai; BENDER, Eckhard; SCOTT, William J.; RICHTER, Anja; ZORN, Ludwig; LIU, Ningshu; MOeNNING, Ursula; SIEGEL, Franziska; GOLZ, Stefan; HAeGEBARTH, Andrea; LIENAU, Philip; PUEHLER, Florian; BASTING, Daniel; SCHNEIDER, Dirk; MOeWES, Manfred; WO2014\/147021; (2014); A2;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[463,131],"tags":[126],"class_list":["post-6302","post","type-post","status-publish","format-standard","hentry","category-16034-48-3","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nExtended knowledge of<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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