{"id":6243,"date":"2021-09-09T03:14:58","date_gmt":"2021-09-08T19:14:58","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6243"},"modified":"2021-09-09T03:14:58","modified_gmt":"2021-09-08T19:14:58","slug":"9-sep-2021-news-continuously-updated-synthesis-method-about-95162-14-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6243","title":{"rendered":"9-Sep-2021 News Continuously updated synthesis method about 95162-14-4"},"content":{"rendered":"

Related Products of 95162-14-4<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 95162-14-4 as follows.<\/p>\n

Intermediate 12: Methyl [N- (TERT-BUTOXVCARBONYL)-4- (1-TRITYL-1H-PVRAZOL-4-VL)-L-PHENVLALANINATE] To a mixture of [BROMOPYRAZOLE] (11) (1. 0g, 2. [56MOL),] boronic acid (1) (0.7g, 2. [14MMOL),] and potassium carbonate (1.5g, 10. [7MMOL)] in degassed DME [(10ML)] was added [PDCI2 [DPPF]] (0.088g, [0.] [1MMOL).] The reaction mixture was then heated to [70C] under nitrogen for 24 hours. Solvent was then removed in vacuo, and the residue was partitioned between ethyl acetate and water. The organic portion was dried over sodium sulphate and solvent evaporated in vacuo to give the crude product. Purification via silica gel chromatography (ethyl acetate\/petroleum ether 40-60 1: 4) gave the title compound (0.74g) LCMS RT 4.11 min, [[CPH3] + 243]<\/p>\n

According to the analysis of related databases, 95162-14-4, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; GLAXO GROUP LIMITED; WO2003\/104200; (2003); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 95162-14-4, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[252,131],"tags":[167],"class_list":["post-6243","post","type-post","status-publish","format-standard","hentry","category-95162-14-4","category-pyrazoles-derivatives","tag-m-w300-400"],"yoast_head":"\nContinuously updated synthesis method about<\/title>\n<meta name=\"description\" content=\"Related Products of 95162-14-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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