{"id":6172,"date":"2021-09-03T03:56:09","date_gmt":"2021-09-02T19:56:09","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6172"},"modified":"2021-09-03T03:56:09","modified_gmt":"2021-09-02T19:56:09","slug":"9-3-2021-news-the-important-role-of-5952-93-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6172","title":{"rendered":"9\/3\/2021 News The important role of 5952-93-2"},"content":{"rendered":"

Application of 5952-93-2<\/a>, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5952-93-2, name is Methyl 1-methyl-1H-pyrazole-4-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.<\/p>\n

General procedure: To a solution of methyl 1-(methylcarbamoyl)-1H-pyrazole-3- carboxylate, Example 395.1 (0.943 g, 5.15 mmol) in MeOH (10 mL, 247 mmol), was added hydrazine (0.236 mL, 10.30 mmol) at RT. The resulting mixture was stirred at RT for 24 h. The mixture was then concentrated in vacuo and the residue was dissolved in water (100 mL). The aqueous solution was lyophilized to give the title compound (943 mg). LCMS-ESI (pos.): 184.1 (M+H)+.<\/p>\n

The synthetic route of Methyl 1-methyl-1H-pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; AMGEN INC.; CHEN, Ning; CHEN, Xiaoqi; CHEN, Yinhong; CHENG, Alan C.; CONNORS, Richard V.; DEIGNAN, Jeffrey; DRANSFIELD, Paul John; DU, Xiaohui; FU, Zice; HARVEY, James S.; HEATH, Julie Anne; HEUMANN, Lars V.; HORNE, Daniel B.; HOUZE, Jonathan; KALLER, Matthew R.; KAYSER, Frank; KHAKOO, Aarif Yusuf; KOPECKY, David J.; LAI, Su-Jen; MA, Zhihua; MEDINA, Julio C.; MIHALIC, Jeffrey T.; NISHIMURA, Nobuko; OLSON, Steven H.; PATTAROPONG, Vatee; SWAMINATH, Gayathri; WANG, Xiaodong; WANSKA, Malgorzata; YANG, Kevin; YEH, Wen-Chen; (700 pag.)WO2018\/97945; (2018); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of Methyl 1-methyl-1H-pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[689,131],"tags":[126],"class_list":["post-6172","post","type-post","status-publish","format-standard","hentry","category-5952-93-2","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of<\/title>\n<meta name=\"description\" content=\"Application of 5952-93-2, In the next few decades, the world population will flourish. 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