{"id":6153,"date":"2021-09-02T03:42:17","date_gmt":"2021-09-01T19:42:17","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6153"},"modified":"2021-09-02T03:42:17","modified_gmt":"2021-09-01T19:42:17","slug":"9-2-2021-news-application-of-151049-87-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6153","title":{"rendered":"9\/2\/2021 News Application of 151049-87-5"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 151049-87-5, name is 3-Bromo-1-methyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 151049-87-5, name: 3-Bromo-1-methyl-1H-pyrazole<\/a><\/p>\n

To a solution of 3-bromo-1-methyl-1H-pyrazole (650 mg, 4.O4mmol) in acetonitrile(10 mL) was added 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octanebis(tetrafluoroborate) (2.15 g, 6.06 mmol). The mixture wasstirred room temperature for 72 h. The reaction was concentrated in vacuo and the residue was dissolved in ethyl acetate (20 mL), washed with saturated sodium bicarbonate (20 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was purified via flash silica chromatography (solvent gradient: 0-2% ethyl acetate in petroleum ether) to yield 150 mg crude of the title compound as a white solid.<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n

Reference:
Patent; GENENTECH, INC.; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; BRAUN, Marie-Gabrielle; GIBBONS, Paul; LEE, Wendy; LY, Cuong; RUDOLPH, Joachim; SCHWARZ, Jacob; ASHKENAZI, Avi; FU, Leo; LAI, Tommy; WANG, Fei; BEVERIDGE, Ramsay; ZHAO, Liang; (652 pag.)WO2018\/166528; (2018); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[331,131],"tags":[126],"class_list":["post-6153","post","type-post","status-publish","format-standard","hentry","category-151049-87-5","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nApplication of<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 151049-87-5, name is 3-Bromo-1-methyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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