{"id":6150,"date":"2021-09-02T03:42:17","date_gmt":"2021-09-01T19:42:17","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6150"},"modified":"2021-09-02T03:42:17","modified_gmt":"2021-09-01T19:42:17","slug":"9-2-2021-news-extended-knowledge-of-37622-90-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6150","title":{"rendered":"9\/2\/2021 News Extended knowledge of 37622-90-5"},"content":{"rendered":"

37622-90-5, name is Ethyl 4-pyrazolecarboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of Ethyl 4-pyrazolecarboxylate<\/a><\/p>\n

[1326] to a solution of ethyl 1H-pyrazole-4-carboxylate (5 g, 35.68 mmol) and Cs2CO3 (23.25 g, 71.36 mmol) in DMF(100 ml) was added mel (10.13 g, 71.36 mmol, 4.44 ml). The mixture was stirred at 25c for 16h. The mixture was filtered, the filtrate was diluted with H2O (500 ml), extracted with ea (50 ml x 3), dried over Na2SO4, filtered and concentrated to give a residue. The residue was purified by column chromatography (SiO2, petroleum ether\/ethyl acetate = 5\/1). Compound 282a (4.5 g, yield: 81.81%) was obtained as a yellow oil. 1H NMR (400mhz, CDCl3) delta 7.84 (d, = 8.5 hz, 2h), 4.24 (q, = 7.3 hz, 2h), 4.03-3.70 (m, 3h), 1.30 (t, j = 7.2 hz, 3h). MS (ESI) m\/z (M+H)+155.0.<\/p>\n

The synthetic route of 37622-90-5 has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; BLADE THERAPEUTICS, INC.; BUCKMAN, Brad, Owen; YUAN, Shendong; ADLER, Marc; EMAYAN, Kumaraswamy; MA, Jingyuang; (687 pag.)WO2018\/64119; (2018); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 37622-90-5 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[218,131],"tags":[126],"class_list":["post-6150","post","type-post","status-publish","format-standard","hentry","category-37622-90-5","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nExtended knowledge of<\/title>\n<meta name=\"description\" content=\"37622-90-5, name is Ethyl 4-pyrazolecarboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 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