{"id":6124,"date":"2021-09-01T07:11:29","date_gmt":"2021-08-31T23:11:29","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6124"},"modified":"2021-09-01T07:11:29","modified_gmt":"2021-08-31T23:11:29","slug":"9-1-21-news-a-new-synthetic-route-of-114474-28-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6124","title":{"rendered":"9\/1\/21 News A new synthetic route of 114474-28-1"},"content":{"rendered":"

Synthetic Route of 114474-28-1<\/a>, The chemical industry reduces the impact on the environment during synthesis 114474-28-1, name is 4-(1H-Pyrazol-4-yl)aniline, I believe this compound will play a more active role in future production and life.<\/p>\n

[0244] A mixture of 5,7-dichloro-l-methyl-lH-pyrazolo[4,3-d]pyrimidine (300 mg, 1.50 mmol), 4-(lH-pyrazol-4-yl)aniline (235, 1.50 mmol), and iPr2NEt (0.52 mL, 0.74 mmol) in DMF (3.0 mL) was heated at 100 C for 5h, cooled to rt, and diluted with water. The precipitate formed was collected by filtration and washed with water and dried in vacuo to provide the title compound (465 mg, 97%). MS(ES+) m\/e 326 (M+H)+.<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(1H-Pyrazol-4-yl)aniline, other downstream synthetic routes, hurry up and to see.<\/p>\n

Reference:
Patent; KADMON CORPORATION, LLC; OLSZEWSKI, Kellen; KIM, Ji-In; POYUROVSKY, Masha; LIU, Kevin; BARSOTTI, Anthony; MORRIS, Koi; (344 pag.)WO2016\/210330; (2016); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(1H-Pyrazol-4-yl)aniline, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[408,131],"tags":[126],"class_list":["post-6124","post","type-post","status-publish","format-standard","hentry","category-114474-28-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nA new synthetic route of<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 114474-28-1, The chemical industry reduces the impact on the environment during synthesis 114474-28-1, name is 4-(1H-Pyrazol-4-yl)aniline, I believe this compound will play a more active role in future production and life.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=6124\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A new synthetic route of\" \/>\n<meta property=\"og:description\" content=\"Synthetic Route of 114474-28-1, The chemical industry reduces the impact on the environment during synthesis 114474-28-1, name is 4-(1H-Pyrazol-4-yl)aniline, I believe this compound will play a more active role in future production and life.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=6124\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-08-31T23:11:29+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=6124\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=6124\",\"name\":\"A new synthetic route of\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-08-31T23:11:29+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Synthetic Route of 114474-28-1, The chemical industry reduces the impact on the environment during synthesis 114474-28-1, name is 4-(1H-Pyrazol-4-yl)aniline, I believe this compound will play a more active role in future production and life.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=6124#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=6124\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=6124#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"9\/1\/21 News A new synthetic route of 114474-28-1\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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