{"id":6114,"date":"2021-08-31T04:04:15","date_gmt":"2021-08-30T20:04:15","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6114"},"modified":"2021-08-31T04:04:15","modified_gmt":"2021-08-30T20:04:15","slug":"brief-introduction-of-c14h22n4o4-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6114","title":{"rendered":"Brief introduction of C14H22N4O4"},"content":{"rendered":"<p><a href=\"https:\/\/www.ambeed.com\/products\/152120-54-2.html\">Application of 152120-54-2<\/a>, These common heterocyclic compound, 152120-54-2, name is tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n<p>General procedure: N,N-diBoc-1H-pirazole-1-carboxamidine (0.8 g, 1eq) was dissolved in anhydrous THF (10 mL), then triphenylphosphine (1.01 g, 1.5eq) and the appropriate alcohol (1.3 eq) were. The mixture was then cooled to 0 C and DIAD (0.76 mL, 1.5eq) was added dropwise. The temperature was raised to reflux and stirred overnight. The reaction was quenched with H2O and extracted with CH2Cl2 (3 x 30 mL). The combined organic phases were washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure. The crude products were purified by flash column chromatography (SiO2) using 1:9 AcOEt \/ Petroleum ether as the eluent to yield the guanilated agent.<\/p>\n<p>Statistics shows that tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate is playing an increasingly important role. we look forward to future research findings about 152120-54-2.<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.bmcl.2014.09.081\">Article; Maccari, Giorgio; Sanfilippo, Stefania; De Luca, Filomena; Deodato, Davide; Casian, Alexandru; Dasso Lang, Maria Chiara; Zamperini, Claudio; Dreassi, Elena; Rossolini, Gian Maria; Docquier, Jean-Denis; Botta, Maurizio; Bioorganic and Medicinal Chemistry Letters; vol. 24; 23; (2014); p. 5525 &#8211; 5529;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Statistics shows that tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate is playing an increasingly important role. we look forward to future research findings about 152120-54-2.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[254,131],"tags":[167],"class_list":["post-6114","post","type-post","status-publish","format-standard","hentry","category-152120-54-2","category-pyrazoles-derivatives","tag-m-w300-400"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - 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