{"id":6113,"date":"2021-08-31T04:04:15","date_gmt":"2021-08-30T20:04:15","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6113"},"modified":"2021-08-31T04:04:15","modified_gmt":"2021-08-30T20:04:15","slug":"introduction-of-a-new-synthetic-route-about-113100-53-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6113","title":{"rendered":"Introduction of a new synthetic route about 113100-53-1"},"content":{"rendered":"

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 113100-53-1 as follows. Recommanded Product: 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid<\/a><\/p>\n

General procedure: To a solution of carboxylic acid (1 equiv) in CH2Cl2 or DMF (1 mL) was added HOBt (1.2 equiv) and DIEA (2 equiv). After the mixture was stirred at room temperature for 5 min, EDCI (1.1 equiv) and corresponding amine (1.3 equiv) were added. The mixture was stirred overnight, diluted with ethyl acetate (40 mL), washed with 1 N HCl (10 mL), saturated NaHCO3 (20 mL), H2O (20 mL), brine (20 mL), dried over Na2SO4, and concentrated in vacuo. The crude product was purified by column chromatography on silica gel.<\/p>\n

According to the analysis of related databases, 113100-53-1, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Article; Cheng, Gang; Muench, Stephen P.; Zhou, Ying; Afanador, Gustavo A.; Mui, Ernest J.; Fomovska, Alina; Lai, Bo Shiun; Prigge, Sean T.; Woods, Stuart; Roberts, Craig W.; Hickman, Mark R.; Lee, Patty J.; Leed, Susan E.; Auschwitz, Jennifer M.; Rice, David W.; McLeod, Rima; Bioorganic and Medicinal Chemistry Letters; vol. 23; 7; (2013); p. 2035 – 2043;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 113100-53-1, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[195,131],"tags":[126],"class_list":["post-6113","post","type-post","status-publish","format-standard","hentry","category-113100-53-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nIntroduction of a new synthetic route about<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 113100-53-1 as follows. 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