{"id":6108,"date":"2021-08-31T04:04:15","date_gmt":"2021-08-30T20:04:15","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6108"},"modified":"2021-08-31T04:04:15","modified_gmt":"2021-08-30T20:04:15","slug":"new-downstream-synthetic-route-of-741717-63-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6108","title":{"rendered":"New downstream synthetic route of 741717-63-5"},"content":{"rendered":"

Reference of 741717-63-5<\/a>, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 741717-63-5, name is Ethyl 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.<\/p>\n

To a solution of ethyl l-phenyl-3- (trifluoromethyl) -IH- pyrazole-4-carboxylate (0.800 g, 2.81 mmol) in EtOH (20 mL) and THF (5 mL) was added 2M aqueous sodium hydroxide (1.69 mL, 8.44 mmol) . The mixture was heated to reflux until TLC indicated completion, cooled to room temperature, and concentrated in vacuo. The residue was dissolved in water and washed with ether. The aqueous layer was then adjusted to pH~4 with 10% HCl. The solid was collected by filtration and dried under vacuum to give l-phenyl-3- (trifluoromethyl) -lH-pyrazole- 4-carboxylic acid (0.560 g, 78%) as a white powder: 1H NMR (400 MHz, DMSO-d6) delta 7.47 (m, IH), 7.58 (m, 2H), 7.94 (m, 2H), 9.24 (bs, IH); m\/z (APCI neg) 254.9 (100%) [M-H] .<\/p>\n

The chemical industry reduces the impact on the environment during synthesis Ethyl 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate. I believe this compound will play a more active role in future production and life.<\/p>\n

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2008\/11130; (2008); A2;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The chemical industry reduces the impact on the environment during synthesis Ethyl 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[361,131],"tags":[127],"class_list":["post-6108","post","type-post","status-publish","format-standard","hentry","category-741717-63-5","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nNew downstream synthetic route of<\/title>\n<meta name=\"description\" content=\"Reference of 741717-63-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 741717-63-5, name is Ethyl 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate, This compound has unique chemical properties. 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