{"id":6097,"date":"2021-08-31T04:04:15","date_gmt":"2021-08-30T20:04:15","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6097"},"modified":"2021-08-31T04:04:15","modified_gmt":"2021-08-30T20:04:15","slug":"some-tips-on-c5h6n2o","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6097","title":{"rendered":"Some tips on C5H6N2O"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 25016-11-9, name is 1-Methyl-1H-pyrazole-4-carbaldehyde, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25016-11-9, COA of Formula: C5H6N2O<\/a><\/p>\n

A solution of 1-methyl-1H-pyrazole-4-carbaldehyde (2.73 g, 24.80 mmol), (R)-2-methyl-2-propanesulfinamide (3.30 g, 27.30 mmol), and Ti(OiPr)4 (35.2 g, 37.1 mL, 0.124 mol) in THF (60 mL) was stirred with heating on a water bath at 50 C for 20 h. The resulting mixture was poured into water (100 mL) with stirring for 15 min, then filtered and the precipitate was washed twice with DCM. The filtrate was diluted with water (100 mL) and extracted with DCM (20 mL * 3). The combined extracts were dried over K2CO3, filtered through the pad of silica gel, and evaporated under reduced pressure and dried in vacuo to afford pure 2b 5.16 g (97%). = -130.7 (c 1, CHCl3), 1H NMR (400 MHz, CDCl3): delta 8.41 (s, 1H, CH=N), 7.83 (s, 1H, CHpyr), 7.78 (s, 1H, CHpyr), 3.89 (s, 3H, Me), 1.15 (s, 9H, tBu). 13C NMR (100 MHz, CDCl3): delta 154.28, 139.91, 132.14, 119.86, 57.30, 39.29, 22.39 3C. MS (70 eV, EI): m\/z (%) = 214 (60) [MH]+, 157 (100), 130 (10), 109 (56), 108 (48), 83 (18), 82 (20), 81 (8), 41 (7). C9H15N3OS (213.3): calcd C 50.68, H 7.09, N 19.70, S 15.03, found C 50.42, H 7.11, N 19.55, S 14.88.<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-pyrazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.<\/p>\n

Reference:
Article; Kuznetsov, Nikolai Yu.; Khrustalev, Victor N.; Strelkova, Tatyana V.; Bubnov, Yuri N.; Tetrahedron Asymmetry; vol. 25; 8; (2014); p. 667 – 676;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-pyrazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[151,131],"tags":[126],"class_list":["post-6097","post","type-post","status-publish","format-standard","hentry","category-25016-11-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSome tips on<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 25016-11-9, name is 1-Methyl-1H-pyrazole-4-carbaldehyde, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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