{"id":6090,"date":"2021-08-30T03:23:47","date_gmt":"2021-08-29T19:23:47","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6090"},"modified":"2021-08-30T03:23:47","modified_gmt":"2021-08-29T19:23:47","slug":"new-learning-discoveries-about-4-bromo-1-cyclopropyl-1h-pyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6090","title":{"rendered":"New learning discoveries about 4-Bromo-1-cyclopropyl-1H-pyrazole"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 1151802-23-1, name is 4-Bromo-1-cyclopropyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1151802-23-1, Application In Synthesis of 4-Bromo-1-cyclopropyl-1H-pyrazole<\/a><\/p>\n

Step 1 : l-Cyclopropyl-4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-lH-pyridaziiie To a 100 n L flask is added 4-bromo-l-cyclopropylpyrazol (6.57 g, 35.1 mmol) and anhydrous THF (30 niL). The solution is cooled to -78 C under nitrogen; then n-butyl lithium (15.5 n L, 2.5 M in hexanes, 38.6 mmol) is added dropwise. The reaction mixture is stirred at the temperature for 1 hr, followed by addition of isopropyl boronate (9.17 g, 94.1 mmol) and stirred below -70 C for 3 hours. The reaction is quenched with water (20 n L) and the resulted mixture is adjusted to pH 8-9 with aqueous hydrochloride solution (1 N). The combined organic phases are concentrated and used in next step without further purification (6.64 g, 81% yield). (MS: [M+l] 235)<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n

Reference:
Patent; CROWN BIOSCIENCE INC. (TAICANG); ZHONG, Boyu; SHIH, Chuan; YUAN, Hongbin; ZHOU, Feng; WO2014\/32498; (2014); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[520,131],"tags":[126],"class_list":["post-6090","post","type-post","status-publish","format-standard","hentry","category-1151802-23-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nNew learning discoveries about<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 1151802-23-1, name is 4-Bromo-1-cyclopropyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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