{"id":6058,"date":"2021-08-27T03:37:33","date_gmt":"2021-08-26T19:37:33","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6058"},"modified":"2021-08-27T03:37:33","modified_gmt":"2021-08-26T19:37:33","slug":"brief-introduction-of-35-dimethyl-4-iodopyrazole-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6058","title":{"rendered":"Brief introduction of 3,5-Dimethyl-4-iodopyrazole"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2033-45-6, name is 3,5-Dimethyl-4-iodopyrazole, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 3,5-Dimethyl-4-iodopyrazole<\/a><\/p>\n

To a solution of 3,5-Dimethyl-4-iodo-1 H-pyrazole (1 .69g, 7.61 mmol) in DCM (25ml_) was added 3,4- Dihydro-2H-pyran (1 .04mL, 1 1 .4mmol) and pyridinium p-toluenesulfonate (383mg, 1 .52mmol). The reaction was stirred at 40C overnight and then for for 4 days at room temperature. The mixture was diluted with DCM (50ml), washed with sat NaHC03 aq (50ml), dried over Na2S04, filtered and concentrated in vacuo. The residue was purified by flash column chromatography (40g Si02, 0-30% EtOAc in heptane) to provide 4-iodo-3,5-dimethyl-1 -tetrahydropyran-2-yl-pyrazole (2.36g,7.7mmol, 101 .19% yield) as a white solid. MS Method 2: RT: 1 .78 min, ES+ m\/z 307.0 [M+H]+ H NMR (400MHz, CDCI3) delta\/ppm: 5.23-5.26 (d, J=10.4Hz, 1 H), 4.05-4.08 (m, 1 H), 3.62-3.69 (m, 1 H), 2.39-2.49 (m, 1 H), 2.35 (s, 3H), 2.25 (s, 3H), 2.09-2.14 (m, 1 H). 1 .88-1 .94 (m, 1 H), 1 .64-1 .79 (m, 3H).<\/p>\n

According to the analysis of related databases, 2033-45-6, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; REDX PHARMA PLC; BHAMRA, Inder; BINGHAM, Matilda; TESTAR, Richard; SARGENT, Louise; DONOGHUE, Craig; (128 pag.)WO2016\/55786; (2016); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 2033-45-6, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[316,131],"tags":[127],"class_list":["post-6058","post","type-post","status-publish","format-standard","hentry","category-2033-45-6","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nBrief introduction of<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2033-45-6, name is 3,5-Dimethyl-4-iodopyrazole, This compound has unique chemical properties. 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