{"id":6041,"date":"2021-08-26T03:15:58","date_gmt":"2021-08-25T19:15:58","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6041"},"modified":"2021-08-26T03:15:58","modified_gmt":"2021-08-25T19:15:58","slug":"sources-of-common-compounds-c4h5cln2o2s-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6041","title":{"rendered":"Sources of common compounds: C4H5ClN2O2S"},"content":{"rendered":"

Some common heterocyclic compound, 89501-90-6, name is 1-Methyl-1H-pyrazole-3-sulfonyl chloride, molecular formula is C4H5ClN2O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 1-Methyl-1H-pyrazole-3-sulfonyl chloride<\/a><\/p>\n

Ui) l-Methyl-lH-pyrazole-3-sulfonic acid benzyl-(l-oxo-l,2,3,4-tetrahydro- isoquinolin-6-yl)-amideTo a stirred solution of 6-benzylamino-3,4-dihydro-2H-isoquinolin-l-one (45 mg, 0.18 mmol) and pyridine (31 mul, 0.39 mmol) in anhydrous acetonitrile (1 ml) was added 1- methyl-lH-pyrazole-3-sulfonyl chloride (70 mg, 0.39 mmol) and the reaction heated to 1500C in a microwave for 0.5 hrs. The solvent was evaporated in vacuo and the crude residue purified by preparative tic (5% methanol in dichloromethane) to afford the title compound as a yellow solid (10 mg, 14%). HPLC retention time 3.83 min. Mass spectrum (ES+) m\/z 397 (M+H).<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 89501-90-6, its application will become more common.<\/p>\n

Reference:
Patent; XENTION LIMITED; HAMLYN, Richard, John; MADGE, David; MULLA, Mushtaq; WO2010\/139953; (2010); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 89501-90-6, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[181,131],"tags":[126],"class_list":["post-6041","post","type-post","status-publish","format-standard","hentry","category-89501-90-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSources of common compounds:<\/title>\n<meta name=\"description\" content=\"Some common heterocyclic compound, 89501-90-6, name is 1-Methyl-1H-pyrazole-3-sulfonyl chloride, molecular formula is C4H5ClN2O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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