{"id":6033,"date":"2021-08-26T03:15:58","date_gmt":"2021-08-25T19:15:58","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6033"},"modified":"2021-08-26T03:15:58","modified_gmt":"2021-08-25T19:15:58","slug":"a-new-synthetic-route-of-c6h7brn2o","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6033","title":{"rendered":"A new synthetic route of C6H7BrN2O"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 706819-66-1, name is 2-Bromo-1-(1-methyl-1H-pyrazol-4-yl)ethanone, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H7BrN2O<\/a><\/p>\n

2-bromo-1-(1-methyl-1H-pyrazol-4-yl)-ethanone (0.5 g; 2.46 mmol) in DMF (10 mL) were added to potassium phtalimide (0.46 g; 2.46 mmol). The reaction mixture wasstirred at RT for 5h, poured into water-ice and EtOAc was added. The organic layer was separated, washed with water, brine, dried over Mg504, filtered and evaporated till dryness. The residue was purified by chromatography over silica gel (irregular SiOH 15-40.im, 24g; mobile phase: 97% DCM, 3% MeOH (+10% NH4OH)). The pure fractions were collected and evaporated to dryness yielding 460 mg (69%) of intermediate 86.<\/p>\n

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 706819-66-1.<\/p>\n

Reference:
Patent; JANSSEN PHARMACEUTICA NV; ANGIBAUD, Patrick, Rene; PANDE, Vineet; HERKERT, Barbara; KROSKY, Daniel, Jason; QUEROLLE, Olivier, Alexis, Georges; PILATTE, Isabelle, Noelle, Constance; PATRICK, Aaron, Nathaniel; (250 pag.)WO2018\/50686; (2018); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 706819-66-1.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[270,131],"tags":[127],"class_list":["post-6033","post","type-post","status-publish","format-standard","hentry","category-706819-66-1","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nA new synthetic route of<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 706819-66-1, name is 2-Bromo-1-(1-methyl-1H-pyrazol-4-yl)ethanone, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H7BrN2O\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=6033\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A new synthetic route of\" \/>\n<meta property=\"og:description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 706819-66-1, name is 2-Bromo-1-(1-methyl-1H-pyrazol-4-yl)ethanone, This compound has unique chemical properties. 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