{"id":6006,"date":"2021-08-24T03:15:24","date_gmt":"2021-08-23T19:15:24","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6006"},"modified":"2021-08-24T03:15:24","modified_gmt":"2021-08-23T19:15:24","slug":"the-origin-of-a-common-compound-about-1h-pyrazole-4-carbonitrile-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6006","title":{"rendered":"The origin of a common compound about 1H-Pyrazole-4-carbonitrile"},"content":{"rendered":"<p>Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, A new synthetic method of this compound is introduced below., <a href=\"https:\/\/www.ambeed.com\/products\/31108-57-3.html\">Recommanded Product: 1H-Pyrazole-4-carbonitrile<\/a><\/p>\n<p>To a suspension of K2CO3 (63 mg, 0.46 mmol) in THF (10 mL) was added 4-cyanopyrazole (43 mg, 0.46 mmol) and compound SB-W (100 mg, 0.23 mmol). After stirring at room temperature for 15h, the reaction mixture was poured into 5 mL H20 and extracted with EtOAc (2 x 10 mL). The combined organic layers were washed with brine (2 x 10 mL), dried over sodium sulfate,filtered and concentrated under vacuum. The residue was purified by reverse-phase prep-HPLC to afford SB-9 as a white solid (43.5 mg, 0.095 mmol, 41.7%). 1HNMR (500 MHz, CDC13) delta (ppm7.86 (IH, s), 7.82 (IH, s), 5.01 (IH, AB), 4.91 (IH, AB), 3.53 (2H, q), 3.22 (2H, s), 2.61 (IH, t), 0.67 (3H, s), 0.67-2.25 (24H, m). LCMS: Rt = 2.37 mm. m\/z = 454.4 [M+H]+<\/p>\n<p>The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n<p>Reference:<br \/><a href=\"http:\/\/v3.espacenet.com\/textdoc?DB=EPODOC&#038;IDX=WO2014169833&#038;F=0\">Patent; SAGE THERAPEUTICS, INC.; BOTELLA, Gabriel Martinez; HARRISON, Boyd L.; ROBICHAUD, Albert Jean; SALITURO, Francesco G.; BERESIS, Richard Thomas; WO2014\/169833; (2014); A1;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[326,131],"tags":[145],"class_list":["post-6006","post","type-post","status-publish","format-standard","hentry","category-31108-57-3","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The origin of a common compound about<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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