{"id":6005,"date":"2021-08-24T03:15:24","date_gmt":"2021-08-23T19:15:24","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6005"},"modified":"2021-08-24T03:15:24","modified_gmt":"2021-08-23T19:15:24","slug":"analyzing-the-synthesis-route-of-500011-84-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6005","title":{"rendered":"Analyzing the synthesis route of 500011-84-7"},"content":{"rendered":"

Related Products of 500011-84-7<\/a>,Some common heterocyclic compound, 500011-84-7, name is 3-Bromo-1-(dimethylsulfamoyl)pyrazole, molecular formula is C5H8BrN3O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

To trifluoroacetic acid (70 mL) was slowly added [3-BROMO-N, N-DIMETHYL-LH-] [PYRAZOLE-1-SULFONAMIDE] (i. e. the bromopyrazole product of Step A) (57.04 g). The reaction mixture was stirred at room temperature for 30 minutes and then concentrated at reduced pressure. The residue was taken up in hexane, insoluble solids were filtered off, and the hexane was evaporated to afford the crude product as an oil. The crude product was further purified by chromatography on silica gel using ethyl [ACETATE\/DICHLOROMETHANE] (10: 90) as eluent to afford an oil. The oil was taken up in dichloromethane, neutralized with aqueous sodium bicarbonate solution, extracted with methylene chloride (3x), dried over magnesium sulfate and concentrated to afford the title product as a white solid (25.9 g), m. p. [61-64 C.] [1H] NMR (CDC13) [8] 6.37 (d, 1H), 7.59 (d, 1H), 12.4 (br s, 1H).<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromo-1-(dimethylsulfamoyl)pyrazole, its application will become more common.<\/p>\n

Reference:
Patent; E.I. DU PONT DE NEMOURS AND COMPANY; STEVENSON, Thomas, Martin; WO2003\/106427; (2003); A2;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromo-1-(dimethylsulfamoyl)pyrazole, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[373,131],"tags":[127],"class_list":["post-6005","post","type-post","status-publish","format-standard","hentry","category-500011-84-7","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nAnalyzing the synthesis route of<\/title>\n<meta name=\"description\" content=\"Related Products of 500011-84-7,Some common heterocyclic compound, 500011-84-7, name is 3-Bromo-1-(dimethylsulfamoyl)pyrazole, molecular formula is C5H8BrN3O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=6005\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Analyzing the synthesis route of\" \/>\n<meta property=\"og:description\" content=\"Related Products of 500011-84-7,Some common heterocyclic compound, 500011-84-7, name is 3-Bromo-1-(dimethylsulfamoyl)pyrazole, molecular formula is C5H8BrN3O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=6005\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-08-23T19:15:24+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=6005\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=6005\",\"name\":\"Analyzing the synthesis route of\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-08-23T19:15:24+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Related Products of 500011-84-7,Some common heterocyclic compound, 500011-84-7, name is 3-Bromo-1-(dimethylsulfamoyl)pyrazole, molecular formula is C5H8BrN3O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=6005#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=6005\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=6005#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Analyzing the synthesis route of 500011-84-7\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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