{"id":6000,"date":"2021-08-24T03:15:24","date_gmt":"2021-08-23T19:15:24","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=6000"},"modified":"2021-08-24T03:15:24","modified_gmt":"2021-08-23T19:15:24","slug":"continuously-updated-synthesis-method-about-c7h7f3n2o2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=6000","title":{"rendered":"Continuously updated synthesis method about C7H7F3N2O2"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 155377-19-8, name is Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 155377-19-8, Recommanded Product: Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate<\/a><\/p>\n

(R)-lambda\/-(5-(hydroxymethyl)-2,3-dihydro-1 H-inden-2-yl)propane-2-sulfonamide (2.82 mmol, 760 mg) was dissolved in DCM (20 mL) and Thionyl Chloride (5.64 mmol, 0.409 mL, 671 mg) added and the solution stirred at room temperature. After 45 min the mixture was concentrated then azeotroped with DCM (4 x 10 mL) to give a yellow oil. To this oil was added DMF (10 mL) and potassium carbonate (8.46 mmol, 1170 mg) followed by ethyl 3- (trifluoromethyl)-1 H-pyrazole-4-carboxylate (2.82 mmol, 587 mg) . The mixture was heated to 60 0C with stirring for 1 h. The reaction was concentrated to remove DMF before partitioning between EtOAc\/Water. The phases were mixed and separated and the aqueous phase further washed with EtOAc (x 2). Combined organics were dried and concentrated to give a light yellow oil which was purified on silica eluting with 25% EtOAc\/heptane. Desired fractions were collected and concentrated to give (R)-ethyl 1-((2- (1-methylethylsulfonamido)-2,3-dihydro-‘\/\/-\/-inden-5-yl)methyl)-3-(trifluoromethyl)- 1H- pyrazole-4-carboxylate as a colourless solid (1.1 1 g, 86 %).1H NMR (400 MHz, CDCI3) delta 1.31 (t, 3H) 1.39 (d, 6H) 2.9 (m, 2H) 3.17 (sept, 1 H) 3.30 (m, 2H) 4.30 (m, 4H) 5.28 (s, 2H) 7.13 (m, 2H) 7.25 (d, 1 H) 7.89 (s, 1 H)<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate, and friends who are interested can also refer to it.<\/p>\n

Reference:
Patent; N.V. ORGANON; WO2009\/147167; (2009); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[226,131],"tags":[127],"class_list":["post-6000","post","type-post","status-publish","format-standard","hentry","category-155377-19-8","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nContinuously updated synthesis method about<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 155377-19-8, name is Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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