{"id":5995,"date":"2021-08-24T03:15:24","date_gmt":"2021-08-23T19:15:24","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5995"},"modified":"2021-08-24T03:15:24","modified_gmt":"2021-08-23T19:15:24","slug":"introduction-of-a-new-synthetic-route-about-5-amino-13-dimethylpyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5995","title":{"rendered":"Introduction of a new synthetic route about 5-Amino-1,3-dimethylpyrazole"},"content":{"rendered":"

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3524-32-1, name is 5-Amino-1,3-dimethylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. name: 5-Amino-1,3-dimethylpyrazole<\/a><\/p>\n

To a solution of 5-amino-1,3-dimethylpyrazole (300 mg, 2.70 mmol) in dichloromethane (3 mL) was added at ambient temperature under a nitrogen atmosphere N-BOC-(4′-chlorophenyl)glycine (771 mg, 2.70 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (569 mg, 2.97 mmol), 1-hydroxybenzotriazole (36 mg, 0.27 mmol) and N,N-diisopropyl ethyl amine (693 mul, 4.05 mmol). The resulting reaction mixture was was stirred for 18 h at this temperature. The solution was diluted with ethyl acetate (20 mL) and washed with aqueous sodium carbonate (half saturated, 20 mL), water (20 mL) and brine (20 mL). The combined aqueous layers were extracted with ethyl acetate (20 mL) and the combined organic layers were dried over sodium sulfate. Concentration and purification by chromatography (SiO2, heptane:ethyl acetate=80:20 to 0:100) afforded the title compound (656 mg, 64%) as a colorless oil. MS m\/e: 379.3 [M+H]+.<\/p>\n

The synthetic route of 3524-32-1 has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; Knust, Henner; Nettekoven, Matthias; Pinard, Emmanuel; Roche, Olivier; Rogers-Evans, Mark; US2009\/312314; (2009); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 3524-32-1 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[139,131],"tags":[126],"class_list":["post-5995","post","type-post","status-publish","format-standard","hentry","category-3524-32-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nIntroduction of a new synthetic route about<\/title>\n<meta name=\"description\" content=\"In the next few decades, the world population will flourish. 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