{"id":5963,"date":"2021-08-20T03:06:42","date_gmt":"2021-08-19T19:06:42","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5963"},"modified":"2021-08-20T03:06:42","modified_gmt":"2021-08-19T19:06:42","slug":"extracurricular-laboratory-synthetic-route-of-1150271-23-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5963","title":{"rendered":"Extracurricular laboratory: Synthetic route of 1150271-23-0"},"content":{"rendered":"<p><a href=\"https:\/\/www.ambeed.com\/products\/1150271-23-0.html\">Synthetic Route of 1150271-23-0<\/a>, These common heterocyclic compound, 1150271-23-0, name is tert-Butyl 4-bromo-1H-pyrazole-1-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n<p>tert-Butyl 4-bromopyrazole-1-carboxylate (230 mg, 0.931 mmol), tert-butyl 3- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,5-dihydropyrrole-1-carboxylate (250 mg, 0.847 mmol) and potassium carbonate (1.3 mL of 2M, 2.60 mmol) were combined in dioxane (3 mL) and the mixture de-gassed (x 2 vacuum cycles). Pd(dppf)Cl2.DCM (70 mg, 0.086 mmol) was added and the mixture de-gassed (x 2 vacuum cycles) then heated at 90 C overnight. The reaction mixture was partitioned between EtOAc and water. The organic phase was dried (Na2SO4), filtered and concentraed in vacuo. The residue was purified by chromatography (silica, 0-100% EtOAc\/Petroleum ether gradient elution). Product fractions were combined and concentrated to give the product as a pale yellow film (65 mg, 33%) that was taken on to the next reaction. ESV- MS m\/z 236.0 (M+1) +.<\/p>\n<p>Statistics shows that tert-Butyl 4-bromo-1H-pyrazole-1-carboxylate is playing an increasingly important role. we look forward to future research findings about 1150271-23-0.<\/p>\n<p>Reference:<br \/><a href=\"http:\/\/v3.espacenet.com\/textdoc?DB=EPODOC&#038;IDX=WO2019148136&#038;F=0\">Patent; MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED; BLEICH, Matthew; CHARRIER, Jean-Damien; DONG, Huijun; DURRANT, Steven; ENO, Meredith Suzanne; ETXEBARRIA I JARDI, Gorka; EVERITT, Simon; FRAYSSE, Damien; KNEGTEL, Ronald; MOCHALKIN, Igor; NORTH, Kiri; PORICHIS, Filippos; PULLIN, Robert; QIU, Hui; STORCK, Pierre-Henri; TWIN, Heather Clare; XIAO, Yufang; (312 pag.)WO2019\/148136; (2019); A1;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Statistics shows that tert-Butyl 4-bromo-1H-pyrazole-1-carboxylate is playing an increasingly important role. we look forward to future research findings about 1150271-23-0.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[394,131],"tags":[127],"class_list":["post-5963","post","type-post","status-publish","format-standard","hentry","category-1150271-23-0","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - 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