{"id":5958,"date":"2021-08-20T03:06:42","date_gmt":"2021-08-19T19:06:42","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5958"},"modified":"2021-08-20T03:06:42","modified_gmt":"2021-08-19T19:06:42","slug":"the-important-role-of-152120-54-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5958","title":{"rendered":"The important role of 152120-54-2"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 152120-54-2, name is tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 152120-54-2, Recommanded Product: tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate<\/a><\/p>\n

To a mixture of N,N’-bis(tertbutoxycarbonyl)-1H-pyrazole-1-carboxamidine (2g, 6.44 mmol), triphenylphosphine (2.53g, 9.67 mmol), MeOH (260 muL, 6.44 mmol) and dry THF (20 mL) was added dropwise DIAD ( 1.9 mL, 9.67 mmol) at 0C under argon. The reaction mixture was stirred at room temperature overnight. Then a solid was filtered off and the filtratrate was concentrated under reduced pressure. A residue was washed with hexane (6 x 50mL). Hexane was evaporated and the residue was purified by column chromatography on silica gel (hexane\/AcOEt, 7: 1 to 5: 1) to give tert-butyl (((tert-butoxycarbonyl)imino)(1H-pyrazol-1-yl)methyl)(methyl)carbamate (1.49 g, 71 %) as a colorless oil . ESI+MS: m\/z = 347.1 (M+1)+. 1Eta NMR (700 MHz, Chloroform-d) delta 8.02 (s, 1H), 7.71 (d, J= 1.1 Hz, 1H), 6.45 (ddd, J = 8.7, 2.7, 1.6 Hz, 1H), 3.27 (s, 3H), 1.54 (s, 9H), 1.32 (s, 9H).<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate, other downstream synthetic routes, hurry up and to see.<\/p>\n

Reference:
Patent; ONCOARENDI THERAPEUTICS SP. Z O.O.; B?ASZCZYK, Roman; BRZEZI?SKA, Joanna; GO??BIOWSKI, Adam A.; OLCZAK, Jacek; (93 pag.)WO2016\/108707; (2016); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[254,131],"tags":[167],"class_list":["post-5958","post","type-post","status-publish","format-standard","hentry","category-152120-54-2","category-pyrazoles-derivatives","tag-m-w300-400"],"yoast_head":"\nThe important role of<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 152120-54-2, name is tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 152120-54-2, Recommanded Product: tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=5958\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The important role of\" \/>\n<meta property=\"og:description\" content=\"Adding a certain compound to certain chemical reactions, such as: 152120-54-2, name is tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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