{"id":5957,"date":"2021-08-20T03:06:42","date_gmt":"2021-08-19T19:06:42","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5957"},"modified":"2021-08-20T03:06:42","modified_gmt":"2021-08-19T19:06:42","slug":"extended-knowledge-of-4522-35-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5957","title":{"rendered":"Extended knowledge of 4522-35-4"},"content":{"rendered":"<p>Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4522-35-4, name is 3-Iodo-1H-pyrazole, A new synthetic method of this compound is introduced below., <a href=\"https:\/\/www.ambeed.com\/products\/4522-35-4.html\">HPLC of Formula: C3H3IN2<\/a><\/p>\n<p>INTERMEDIATE 10 1 -(4-Fluorophenyl)-3 -iodo- 1 H-pyrazole A mixture of 3-iodo-lH-pyrazole (1 g, 5.16 mmol), (4-fluorophenyl)boronic acid (0.866 g, 6.19 mmol) and [Cu(Cl) (OH)(Me2NCH2CH2NMe2)]2 (0.479 g, 1.031 mmol) in CH2C12 (20.6 mL) was sealed and stirred at 25 C under an atmosphere of oxygen (balloon) overnight. The reaction was filtered over Celite to remove insoluble solids and the filter was washed well with CH2C12. The filtrate was concentrated in vacuo and purified by flash chromatography (ISCO Combiflash, 40 g silica gel column, 0- 10% EtOAc in hexanes) to afford l-(4-fluorophenyl)-3 -iodo- 1 H-pyrazole, as white solid. LCMS calc. = 288.96; found = 288.86 (M+H)+.<\/p>\n<p>The synthetic route of 4522-35-4 has been constantly updated, and we look forward to future research findings.<\/p>\n<p>Reference:<br \/><a href=\"http:\/\/v3.espacenet.com\/textdoc?DB=EPODOC&#038;IDX=WO2014120346&#038;F=0\">Patent; MERCK SHARP &amp; DOHME CORP.; MOCHIDA PHARMACEUTICAL CO., LTD.; SMITH, Cameron, James; TAN, John, Qiang; ZHANG, Ting; BALKOVEC, James; GREENLEE, William, John; GUO, Liangqin; XU, Jiayi; CHEN, Yi-heng; CHEN, Yili; CHACKALAMANNIL, Samuel; HIRABAYASHI, Tomokazu; NAGASUE, Hiroshi; OGAWA, Kouki; WO2014\/120346; (2014); A1;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The synthetic route of 4522-35-4 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[147,131],"tags":[126],"class_list":["post-5957","post","type-post","status-publish","format-standard","hentry","category-4522-35-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Extended knowledge of<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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