{"id":5934,"date":"2021-08-19T03:07:22","date_gmt":"2021-08-18T19:07:22","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5934"},"modified":"2021-08-19T03:07:22","modified_gmt":"2021-08-18T19:07:22","slug":"a-new-synthetic-route-of-152120-54-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5934","title":{"rendered":"A new synthetic route of  152120-54-2"},"content":{"rendered":"<p>These common heterocyclic compound, 152120-54-2, name is tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. <a href=\"https:\/\/www.ambeed.com\/products\/152120-54-2.html\">category: pyrazoles-derivatives<\/a><\/p>\n<p>General procedure: To a stirred solution of N,N?-Di-Boc-1H-pyrazole-1-carboxamidine (1.61 mmol) in dry THF, Ph3P(1.42 mmol) and the appropriate alcohol (2.10 mmol) were added under N2 atmosphere. The solutionwas cooled at 0 C and DIAD (2.42 mmol) was added dropwise. The reaction mixture was stirred atreflux for 16 h. The solvent was evaporated and DCM and water were added. Organic phase wasseparated and the aqueous layer was extracted with DCM. The residue was purified by flashchromatography (Hexane\/AcOEt 9:1) affording desired compound.<\/p>\n<p>The synthetic route of tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate has been constantly updated, and we look forward to future research findings.<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.bmcl.2014.09.081\">Article; Maccari, Giorgio; Deodato, Davide; Fiorucci, Diego; Orofino, Francesco; Truglio, Giuseppina I.; Pasero, Carolina; Martini, Riccardo; De Luca, Filomena; Docquier, Jean-Denis; Botta, Maurizio; Bioorganic and Medicinal Chemistry Letters; vol. 27; 15; (2017); p. 3332 &#8211; 3336;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The synthetic route of tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[254,131],"tags":[167],"class_list":["post-5934","post","type-post","status-publish","format-standard","hentry","category-152120-54-2","category-pyrazoles-derivatives","tag-m-w300-400"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - 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