{"id":5914,"date":"2021-08-18T03:28:48","date_gmt":"2021-08-17T19:28:48","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5914"},"modified":"2021-08-18T03:28:48","modified_gmt":"2021-08-17T19:28:48","slug":"continuously-updated-synthesis-method-about-c10h11n3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5914","title":{"rendered":"Continuously updated synthesis method about C10H11N3"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 368870-03-5, name is (4-(1H-Pyrazol-1-yl)phenyl)methanamine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 368870-03-5, SDS of cas: 368870-03-5<\/a><\/p>\n

Method 2: General procedure for the preparation of examples 19-21 and 29-31 via urea formation with N,N’-carbonyldiimidazole.The corresponding primary amine (33.7 mg, 0.19 mmol) was dissolved in DMF (0.5 mL) and N,N’-carbonyldiimidazole (31.5 mg, 0.19 mmol) was added. The mixture was stirred for 20 min at room temperature a then the secondary amine (50 mg, 0.19 mmol) was added and the mixture was stirred at 8O0C for 16 h. The product urea was obtained by preparative HPLC purification. l-r3-(2,6-dichlorophenyl)-5-methyl-l,2-oxazol-4-yll-l-methyl-3-r(4-pyrazol-l- ylphenvDmethyllureaThe titel compound was prepared by general method 2 using intermediate 11 and the commercially available (4-pyrazol-l-ylphenyl)methanamine. 1H NMR (400 MHz, CDCl3) delta (ppm) 7.91 (d, 1 H), 7.73 (d, 1 H), 7.57 – 7.62 (m, 2 H), 7.37 (br. s., 3 H), 7.26 (s, 2 H), 6.47 (s, 1 H), 5.01 (t, 1 H), 4.34 (d, 2 H), 3.13 (s, 3 H), 2.46 (s, 3 H); MS (ESI) m\/z 456 [M+H].<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (4-(1H-Pyrazol-1-yl)phenyl)methanamine, other downstream synthetic routes, hurry up and to see.<\/p>\n

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009\/10784; (2009); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (4-(1H-Pyrazol-1-yl)phenyl)methanamine, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[322,131],"tags":[126],"class_list":["post-5914","post","type-post","status-publish","format-standard","hentry","category-368870-03-5","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nContinuously updated synthesis method about<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 368870-03-5, name is (4-(1H-Pyrazol-1-yl)phenyl)methanamine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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