{"id":5897,"date":"2021-08-17T05:04:25","date_gmt":"2021-08-16T21:04:25","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5897"},"modified":"2021-08-17T05:04:25","modified_gmt":"2021-08-16T21:04:25","slug":"new-learning-discoveries-about-c12h12n2o3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5897","title":{"rendered":"New learning discoveries about C12H12N2O3"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1105039-93-7, name is 1-(4-Methoxybenzyl)-1H-pyrazole-4-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1-(4-Methoxybenzyl)-1H-pyrazole-4-carboxylic acid<\/a><\/p>\n

To resin PL-TFP, 1 .4mmol\/g, 150-300um (300 mg) was added a solution of 1 -(4- methoxybenzyl)-1 H-pyrazole-4-carboxylic acid (64 mg, 0.276 mmol) and 4-DMAP (20 mg, 0.164 mmol) in DCM (4 ml)\/DMF (1 ml). After 10 min shaking at rt, Nu,Nu’- diisopropylcarbodiimide (0.172 ml, 1 .102 mmol) was added and the mixture was shaked at rt overnight. The resin (loaded with the activated ester) was filtered and washed with DMF (2ml), DCM (10 ml) and THF (10 ml). The wet resin was suspended in THF (3ml), then pipetted back to flask. A solution of the amine 5-chloro-1 H-indazol-3- yl)methanamine (50 mg, 0.275 mmol) and TEA (230 muIota_, 1 .653 mmol) in THF (2 ml) was added to the resin suspension and the mixture was shaked at rt for 4 days, filtered and washed with THF. The filtrate was diluted with EtOAc and washed with HCI 1 N, aq. sat. NaHC03 and brine. The organic layer was dried (Na2S04), filtered and concentrated. The residue was triturated with ACN (1 ml), the precipitate was filtered, washed with ACN (1 ml) and dried on HV.UPLC RtE= 0.85 min, [M+H]+ = 396.3-398.4, 1H NMR (400 MHz, DMSO-d6) delta ppm 3.71 (s, 3 H) 4.68 (d, 2 H) 5.23 (s, 2 H) 6.70 – 6.99 (m, 2 H) 7.10 – 7.26 (m, 2 H) 7.31 (dd, 1 H) 7.50 (d, 1 H) 7.81 – 7.93 (m, 2 H) 8.20 (s, 1 H) 8.65 (br. s., 1 H) 13.01 (s, 1 H).<\/p>\n

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1105039-93-7.<\/p>\n

Reference:
Patent; NOVARTIS AG; FLOHR, Stefanie; MARKERT, Christian; NAMOTO, Kenji; PIRARD, Bernard; WO2013\/111108; (2013); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1105039-93-7.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[517,131],"tags":[127],"class_list":["post-5897","post","type-post","status-publish","format-standard","hentry","category-1105039-93-7","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nNew learning discoveries about<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1105039-93-7, name is 1-(4-Methoxybenzyl)-1H-pyrazole-4-carboxylic acid, This compound has unique chemical properties. 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