{"id":5896,"date":"2021-08-17T05:04:25","date_gmt":"2021-08-16T21:04:25","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5896"},"modified":"2021-08-17T05:04:25","modified_gmt":"2021-08-16T21:04:25","slug":"research-on-new-synthetic-routes-about-139756-02-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5896","title":{"rendered":"Research on new synthetic routes about 139756-02-8"},"content":{"rendered":"

These common heterocyclic compound, 139756-02-8, name is 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide<\/a><\/p>\n

General procedure: To a solution of 2-aminobenzamide (1.470 mmol, 1.0 eq.) was added to a solution of Terminal Alkyne (1.470 mmol, 1.0 eq.), Tosyl Azide, (1.470 mmol, 1.0eq.), CuI (0.147 mmol, 0.1 eq.), triethylamine (2.941 mmol, 2.0 eq.), in acetonitrile (10 ml) under N2 atmosphere. The mixture was stirred at room temperature for 12 h. After completion of the reaction (as indicated by TLC) the reaction mixture was poured into water (25 mL) and extracted with ethyl acetate (2×25 mL), dried over Na2SO4, concentrated under vacuum to get crude compound which was purified by column chromatography using a mixture of petroleum ether: ethyl acetate to give the desired product as a white solid.<\/p>\n

The synthetic route of 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Article; Srishyalam; Devanna; Basaveswara Rao; Mulakayala, Naveen; Tetrahedron Letters; vol. 58; 30; (2017); p. 2889 – 2892;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[157,131],"tags":[126],"class_list":["post-5896","post","type-post","status-publish","format-standard","hentry","category-139756-02-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nResearch on new synthetic routes about<\/title>\n<meta name=\"description\" content=\"These common heterocyclic compound, 139756-02-8, name is 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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