{"id":5894,"date":"2021-08-17T05:04:25","date_gmt":"2021-08-16T21:04:25","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5894"},"modified":"2021-08-17T05:04:25","modified_gmt":"2021-08-16T21:04:25","slug":"research-on-new-synthetic-routes-about-36650-74-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5894","title":{"rendered":"Research on new synthetic routes about  36650-74-5"},"content":{"rendered":"<p>In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36650-74-5, name is 1H-Pyrazole-3-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. <a href=\"https:\/\/www.ambeed.com\/products\/36650-74-5.html\">COA of Formula: C4H3N3<\/a><\/p>\n<p>To a solution of lH-pyrazole-3-carbonitrile (2.00 g, 21.5 mmol) in EtOH (3 ml) was added ethyl (2R)-oxirane- 2-carboxylate (1.0 g, 8.61 mmol) (for synthesis refer to example 5AY) portionwise. Then the mixture was stirred at 90C for 0.5 h. The reaction mixture was concentrated under reduced pressure to give a residue. The residue was purified by FCC (1 :2 EtOAc \/ petrol) to give the title compound as a colourless oil. Y = 14 %. NMR (400MHz, chloroform-) delta 7.59 (d, J = 3 Hz, 1H), 6.65 (d, J = 3 Hz, 1H), 4.56 &#8211; 4.47 (m, 3H), 4.33 &#8211; 4.25 (m, 2H), 1.35 &#8211; 1.29 (m, 3H).<\/p>\n<p>The synthetic route of 36650-74-5 has been constantly updated, and we look forward to future research findings.<\/p>\n<p>Reference:<br \/><a href=\"http:\/\/v3.espacenet.com\/textdoc?DB=EPODOC&#038;IDX=WO2019025467&#038;F=0\">Patent; NODTHERA LIMITED; BOCK, Mark G.; WATT, Alan Paul; PORTER, Roderick Alan; HARRISON, David; (229 pag.)WO2019\/25467; (2019); A1;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The synthetic route of 36650-74-5 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[357,131],"tags":[145],"class_list":["post-5894","post","type-post","status-publish","format-standard","hentry","category-36650-74-5","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Research on new synthetic routes about<\/title>\n<meta name=\"description\" content=\"In the next few decades, the world population will flourish. 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