{"id":5887,"date":"2021-08-17T05:04:25","date_gmt":"2021-08-16T21:04:25","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5887"},"modified":"2021-08-17T05:04:25","modified_gmt":"2021-08-16T21:04:25","slug":"share-a-compound-1-benzyl-4-iodo-1h-pyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5887","title":{"rendered":"Share a compound : 1-Benzyl-4-iodo-1H-pyrazole"},"content":{"rendered":"

These common heterocyclic compound, 50877-42-4, name is 1-Benzyl-4-iodo-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 1-Benzyl-4-iodo-1H-pyrazole<\/a><\/p>\n

General procedure: A mixture of K2CO3 (0.552 g, 4.0 mmol), Ph3P (5.3 mg,0.02 mmol) and 10% palladium on charcoal (10.6 mg, 0.01 mmol) in EtOH(10 ml) was stirred gently for 30 min, then the hetaryl halide (1.0 mmol) andterminal acetylene (1.2 mmol) were added. The mixture was stirred gently atreflux for 48 h. The resulting precipitate was filtered through a pad of silica geland the EtOH was evaporated. Pure product was isolated by columnchromatography on silica gel using petroleum ether\/EtOAc as eluent<\/p>\n

The synthetic route of 1-Benzyl-4-iodo-1H-pyrazole has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Article; Arsenyan, Pavel; Rubina, Kira; Vasiljeva, Jelena; Belyakov, Sergey; Tetrahedron Letters; vol. 54; 48; (2013); p. 6524 – 6528;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 1-Benzyl-4-iodo-1H-pyrazole has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[472,131],"tags":[127],"class_list":["post-5887","post","type-post","status-publish","format-standard","hentry","category-50877-42-4","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nShare a compound :<\/title>\n<meta name=\"description\" content=\"These common heterocyclic compound, 50877-42-4, name is 1-Benzyl-4-iodo-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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