{"id":5882,"date":"2021-08-16T03:06:32","date_gmt":"2021-08-15T19:06:32","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5882"},"modified":"2021-08-16T03:06:32","modified_gmt":"2021-08-15T19:06:32","slug":"share-a-compound-26621-44-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5882","title":{"rendered":"Share a compound : 26621-44-3"},"content":{"rendered":"

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 26621-44-3, name is 3-Nitro-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Formula: C3H3N3O2<\/a><\/p>\n

To a solution of 3-nitro-1H-pyrazole (3.16 g, 28 mmol) in acetic acid (50 mL) at 0 C was added dropwise fuming HNO3 (2.6 mE, c.a. 58 mmol). Acetic anhydride (6.6 mL, 70 mmcd) was added and the mixture was stirred at it for 3h. The mixture was cooled to 0 C and another portion of fuming HNO3 (0.5 mL, c.a. 11 mmol) was added and the mixture was stirred at it for 2h. The mixture was poured into water, stirred at it overnight, and extracted with EtOAc. The combined organic layers were dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography eluting with 10% EtOAc in petroleum ether to afford 1,3-dinitro-1JJ-pyrazole as a white solid(3.56 g, 81%).<\/p>\n

The synthetic route of 26621-44-3 has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; PLEXXIKON INC.; HOLLADAY, Mark W.; LIU, Gang; (267 pag.)WO2017\/19804; (2017); A2;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 26621-44-3 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[163,131],"tags":[126],"class_list":["post-5882","post","type-post","status-publish","format-standard","hentry","category-26621-44-3","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nShare a compound :<\/title>\n<meta name=\"description\" content=\"In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 26621-44-3, name is 3-Nitro-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Share a compound :","description":"In the next few decades, the world population will flourish. 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