{"id":5871,"date":"2021-08-16T03:06:32","date_gmt":"2021-08-15T19:06:32","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5871"},"modified":"2021-08-16T03:06:32","modified_gmt":"2021-08-15T19:06:32","slug":"the-important-role-of-82560-12-1-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5871","title":{"rendered":"The important role of 82560-12-1"},"content":{"rendered":"

Application of 82560-12-1<\/a>, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 82560-12-1, name is 3-Amino-5-tert-butylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.<\/p>\n

A mixture of 3-tert-butyl-1H-pyrazol-5-amine 7 (0.139 g, 1 mmol), methyl ester 6 (0.199 g, 1 mmol) and DMSO (2 mL) was stirred at ambient temperature during 2 h. After complete disappearance of the starting materials (monitored by TLC), the solid formed was collected by filtration and washed with MeOH\/H2O (1\/2) (3 \u00d7 2 mL), to afford compound 8. Orange solid, 76% yield; m.p: 241-242 C. FTIR nu (cm-1): 3371 (NH), 3316 (NH), 3117, 2955, 1705 (CO), 1625 (CN), 1532 and 1323 (NO2), 1122 (C-O); 1H NMR (CDCl3) delta 1.39 (s, 9H, tBu), 3.95 (s, 3H, OCH3), 5.98 (s, 1H, Pz-CH), 8.06 (d, 1H, J = 9.1 Hz), 8.13 (dd, 1H, J = 9.1 Hz, J = 1.8 Hz), 8.94 (d, 1H, J = 1.8 Hz), 10.07 (bs, 1H, Pz-NH) ppm, the aniline NH is missing; 13C NMR (CDCl3) delta 30.0 (tBu), 31.2 (Cq, tBu), 52.2 (OCH3), 94.9 (Pz-CH), 117.2, 119.5 (Cq), 128.9, 132.1 (Cq), 136.2, 144.3 (Cq), 148.0 (Cq), 154.6 (Cq), 165.5 (CO) ppm. MS (EI) m\/z (%): 318 (100, M+), 287 (15, M – CH3). Anal. Calcd. for C15H18N4O4: C, 56.60; H, 5.70; N, 17.60. Found: C, 56.54; H, 5.83; N, 17.46.<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Amino-5-tert-butylpyrazole, other downstream synthetic routes, hurry up and to see.<\/p>\n

Reference:
Article; Abonia, Rodrigo; Cortes, Edwar; Insuasty, Braulio; Quiroga, Jairo; Nogueras, Manuel; Cobo, Justo; European Journal of Medicinal Chemistry; vol. 46; 9; (2011); p. 4062 – 4070;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Amino-5-tert-butylpyrazole, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[142,131],"tags":[126],"class_list":["post-5871","post","type-post","status-publish","format-standard","hentry","category-82560-12-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of<\/title>\n<meta name=\"description\" content=\"Application of 82560-12-1, In the next few decades, the world population will flourish. 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As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 82560-12-1, name is 3-Amino-5-tert-butylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=5871\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-08-15T19:06:32+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=5871\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=5871\",\"name\":\"The important role of\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-08-15T19:06:32+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Application of 82560-12-1, In the next few decades, the world population will flourish. 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