{"id":5870,"date":"2021-08-16T03:06:32","date_gmt":"2021-08-15T19:06:32","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5870"},"modified":"2021-08-16T03:06:32","modified_gmt":"2021-08-15T19:06:32","slug":"extracurricular-laboratory-synthetic-route-of-120068-79-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5870","title":{"rendered":"Extracurricular laboratory: Synthetic route of 120068-79-3"},"content":{"rendered":"

Reference of 120068-79-3<\/a>, A common heterocyclic compound, 120068-79-3, name is 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile, molecular formula is C11H5Cl2F3N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

0.01 mol of 5-amino-1-(2,6-dichloro-4-trifluoromethyl)-3-cyano-1H-pyrazole was added to a four-necked flask.Heated to 90 C,3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropane formyl isocyanate 0.01 mol and 5 ml of toluene solution were added dropwise.The reaction was refluxed for 5 h.After the reaction is completed, the crystals are cooled and filtered, and filtered.The filter cake was recrystallized from ethanol to give the product 4.82 g. The yield was 81.9%.<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n

Reference:
Patent; Nanjing Tech University; Wan Rong; Qin Xiaofei; Shen Chen; Guo Chunwei; Wu Shaohua; Han Zhenyu; Chen Fuli; (9 pag.)CN104829538; (2018); B;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. 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