{"id":5865,"date":"2021-08-16T03:06:32","date_gmt":"2021-08-15T19:06:32","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5865"},"modified":"2021-08-16T03:06:32","modified_gmt":"2021-08-15T19:06:32","slug":"discovery-of-4-bromo-13-dimethyl-1h-pyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5865","title":{"rendered":"Discovery of 4-Bromo-1,3-dimethyl-1H-pyrazole"},"content":{"rendered":"

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5775-82-6 as follows. name: 4-Bromo-1,3-dimethyl-1H-pyrazole<\/a><\/p>\n

To a suspension of 4-bromo-l,3-dimethyl-pyrazole (5.00 g, 28.60 mmol) in anhydrous 1,4-dioxane (100.0 mL) were added 4,4,4′,4′,5,5,5′,5l-octamethyl-2,2′-bi(l,3,2-dioxaborolane) (8.71 g, 34.32 mmol), acetoxy potassium (5.63 g, 57.41 mmol) and Pd(dppf)2Cl2 dichloromethane complex (2.38 g, 2.86 mmol). The mixture was degassed and refilled with nitrogen for several times and then heated to 100 C and stirred overnight. The mixture was concentrated in vacuo. The residue was diluted with water (30 mL), and the resulting mixture was extracted with EtOAc (50 mLchi3). The combined organic layers was dried over anhydrous Na2S04, filtered and concentrated in vacuo. The residue was purified by silica chromatography (EtOAc\/PE (v\/v) = 1\/20 to 1\/8) to afford the title compound as brown sticky liquid (3.80 g, yield 60%).MS (ESI, pos. ion) m\/z: 223.3 [M+H]+<\/p>\n

According to the analysis of related databases, 5775-82-6, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; XI, Ning; LI, Xiaobo; LI, Mingxiong; ZHANG, Tao; HU, Haiyang; WU, Yanjun; (139 pag.)WO2018\/169700; (2018); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 5775-82-6, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[337,131],"tags":[126],"class_list":["post-5865","post","type-post","status-publish","format-standard","hentry","category-5775-82-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nDiscovery of<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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