{"id":5829,"date":"2021-08-12T03:29:24","date_gmt":"2021-08-11T19:29:24","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5829"},"modified":"2021-08-12T03:29:24","modified_gmt":"2021-08-11T19:29:24","slug":"continuously-updated-synthesis-method-about-c5h4n2o4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5829","title":{"rendered":"Continuously updated synthesis method about C5H4N2O4"},"content":{"rendered":"

These common heterocyclic compound, 3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 1H-Pyrazole-3,5-dicarboxylic acid<\/a><\/p>\n

1H-Pyrazole-3,5-dicarboxylic acid (200 mg, 1.281 mmol), methanamine (2M in THF, 0.705 mL, 1.409 mmol) and HATU (536 mg, 1.409 mmol) were combined in DMF (2 mL). DIPEA (0.448 mL, 2.56 mmol) was added and reaction mixture stirred at rt. under N2 for 2 h. The reaction mixture was concentrated to dryness and used crude for the next step. (0432) LCMS (2 min Formic): Rt = 0.37 min, [MH]+ = 183.1.<\/p>\n

The synthetic route of 1H-Pyrazole-3,5-dicarboxylic acid has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; ATKINSON, Stephen John; DEMONT, Emmanuel Hubert; HARRISON, Lee Andrew; LIWICKI, Gemma Michele; LUCAS, Simon Christopher Cranko; PRESTON, Alexander G; SEAL, Jonathan, Thomas; WALL, Ian David; WATSON, Robert J; (0 pag.)WO2018\/158212; (2018); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 1H-Pyrazole-3,5-dicarboxylic acid has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[140,131],"tags":[126],"class_list":["post-5829","post","type-post","status-publish","format-standard","hentry","category-3112-31-0","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nContinuously updated synthesis method about<\/title>\n<meta name=\"description\" content=\"These common heterocyclic compound, 3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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