{"id":5805,"date":"2021-08-11T05:23:12","date_gmt":"2021-08-10T21:23:12","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5805"},"modified":"2021-08-11T05:23:12","modified_gmt":"2021-08-10T21:23:12","slug":"simple-exploration-of-c6h8n2o2-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5805","title":{"rendered":"Simple exploration of C6H8N2O2"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 37622-90-5, name is Ethyl 4-pyrazolecarboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 37622-90-5, Recommanded Product: Ethyl 4-pyrazolecarboxylate<\/a><\/p>\n

A mixture of 1H-pyrazole-4-carboxylic acid ethyl ester (5.0 g, 35.7 mmol), PIVIBC1 (6.2 g, 39.3 mmol) and K2C03 (7.4 g, 53.6 mmol) in MeCN(100 mL) was refluxed for 16 hrs. Excessive K2C03 was removed by filtration and the filtrate was concentrated to dryness. The residue was purified by silica gel column (PE\/EA = 5\/1) to give 1-(4-methoxy-benzyl)-1H-pyrazole- 4-carboxylic acid ethyl ester (9.5 g, yield: >100%) as a colorless oil.<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n

Reference:
Patent; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; GARDELL, Stephen; PINKERTON, Anthony B.; SERGIENKO, Eduard; SESSIONS, Hampton; (428 pag.)WO2018\/132372; (2018); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[218,131],"tags":[126],"class_list":["post-5805","post","type-post","status-publish","format-standard","hentry","category-37622-90-5","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSimple exploration of<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 37622-90-5, name is Ethyl 4-pyrazolecarboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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