{"id":5804,"date":"2021-08-11T05:23:12","date_gmt":"2021-08-10T21:23:12","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5804"},"modified":"2021-08-11T05:23:12","modified_gmt":"2021-08-10T21:23:12","slug":"continuously-updated-synthesis-method-about-99662-34-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5804","title":{"rendered":"Continuously updated synthesis method about 99662-34-7"},"content":{"rendered":"

Synthetic Route of 99662-34-7<\/a>, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 99662-34-7 name is 4-Pyrazol-1-yl-benzaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.<\/p>\n

[0419] A mixture of 4-(1H-pyrazol-1-yl)benzaldehyde (prepared as described in J. Med Chem. 1998, 41, 2390) (1.65 g, 9.58 mmol), (1,3-dioxolan-2-ylmethyl)triphenylphosphonium bromide (6.45 g, 15.02 mmol), and TDA-1 (3.20 mL, 10.00 mmol) in dichloromethane (50 mL) and sat. aq. K2CO3 (50 mL) was heated to reflux for 20 h. The layers were separated and the aqueous layer was extracted with dichloromethane (2\u00d725 mL). The combined organic layers were washed with water (50 mL) and brine (50 mL), dried (MgSO4), and concentrated. THF (25 mL) and 10% HCl (25 mL) were added and the mixture was stirred for 1 h at rt. The reaction mixture was cooled to 0 C., made basic with 10% NaOH, and extracted with ethyl acetate (3\u00d725 mL). The combined organic layers were washed with water (50 mL) and brine (50 mL), dried (MgSO4), and concentrated. Purification by chromatography (SiO2, 3:1 hexane\/ethyl acetate) provided 1.69 g (89%) of the title compound as a yellow solid. MS 199 (M+H)+.<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Pyrazol-1-yl-benzaldehyde, and friends who are interested can also refer to it.<\/p>\n

Reference:
Patent; Henninger, Todd C.; Macielag, Mark J.; Marinelli, Brett A.; Zhu, Bin; US2004\/18994; (2004); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Pyrazol-1-yl-benzaldehyde, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[478,131],"tags":[126],"class_list":["post-5804","post","type-post","status-publish","format-standard","hentry","category-99662-34-7","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nContinuously updated synthesis method about<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 99662-34-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 99662-34-7 name is 4-Pyrazol-1-yl-benzaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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