{"id":5776,"date":"2021-08-09T05:17:29","date_gmt":"2021-08-08T21:17:29","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5776"},"modified":"2021-08-09T05:17:29","modified_gmt":"2021-08-08T21:17:29","slug":"some-tips-on-5334-39-4-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5776","title":{"rendered":"Some tips on 5334-39-4"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5334-39-4, name is 3-Methyl-4-nitro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Safety of 3-Methyl-4-nitro-1H-pyrazole<\/a><\/p>\n

A solution of 940 mg (2.90 mmol) tert-butyl 4-[(5-methyl-4-nitro-1 H-pyrazol-1 – yl)methyl]piperidine-1 -carboxylate and tert-butyl 4-[(3-methyl-4-nitro-1 H-pyrazol-1 – yl)methyl]piperidine-1 -carboxylate (intermediate 17B) in 5 mL dichloromethane was stirred with 2.2 mL (29.0 mmol) trifluoroacetic acid for three hours. The reaction mixture was filtered over NH2 derivatized silica gel, and the filtrate was evaporated yielding 557 mg of the desired title compounds as crude product which was used without further purification. 1 H NMR (400 MHz, DMSO d6): delta (ppm) = 1.04 \/ 1.11 (m, 2H), 1.39 (m, 2H), 1.89 (m, 1 H), 2.38 (m, 2H), 2.42 \/ 2.60 (s, 3H), 2.90 (m, 2H), 3.95 \/ 4.01 (d, 2H), 8.80 \/ 8.23 (s, 1 H).<\/p>\n

According to the analysis of related databases, 5334-39-4, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BUCHMANN, Bernd; HEISLER, Iring; MUeLLER, Thomas; CLEVE, Arwed; HEROULT, Melanie; NEUHAUS, Roland; PETRUL, Heike; QUANZ-SCHOeFFEL, Maria; (194 pag.)WO2016\/12474; (2016); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 5334-39-4, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[216,131],"tags":[126],"class_list":["post-5776","post","type-post","status-publish","format-standard","hentry","category-5334-39-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSome tips on<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5334-39-4, name is 3-Methyl-4-nitro-1H-pyrazole, This compound has unique chemical properties. 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