{"id":5766,"date":"2021-08-09T05:17:29","date_gmt":"2021-08-08T21:17:29","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5766"},"modified":"2021-08-09T05:17:29","modified_gmt":"2021-08-08T21:17:29","slug":"application-of-82560-12-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5766","title":{"rendered":"Application of 82560-12-1"},"content":{"rendered":"

Some common heterocyclic compound, 82560-12-1, name is 3-Amino-5-tert-butylpyrazole, molecular formula is C7H13N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C7H13N3<\/a><\/p>\n

A mixture of 2,4-dichloro-6-methylpyrimidine (3.52g, 22mmol) and 5-amino-3-tert- butyl-lH-pyrazole (3.00g, 22mmol) and anhydrous sodium carbonate (2.29g, 22mmol) in ethanol (75ml) was stirred at ambient temperature for 24 hours. The insoluble material was removed by filtration and the solvent removed from the filtrate by evaporation. The residue EPO was purified by chromatography on silica gel eluting with EtOAc \/ isohexane (1:3) and then methanol \/ DCM (5:95) to give 2-chloro-6-methyl-4-(5-tert-butyl-lH-pyrazol-3- ylamino)pyrimidine (3.16g, 55%); NMR Spectrum 1.31 (s, 9Eta), 2.19 (s, 3H), 6.15 (s, IH), 7.25 (s, IH), 10.13 (s, IH), 12.14 (s, IH); Mass Spectrum 266 [MH]+.<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 82560-12-1, its application will become more common.<\/p>\n

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006\/100461; (2006); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 82560-12-1, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[142,131],"tags":[126],"class_list":["post-5766","post","type-post","status-publish","format-standard","hentry","category-82560-12-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nApplication of<\/title>\n<meta name=\"description\" content=\"Some common heterocyclic compound, 82560-12-1, name is 3-Amino-5-tert-butylpyrazole, molecular formula is C7H13N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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