{"id":5739,"date":"2021-08-06T03:22:28","date_gmt":"2021-08-05T19:22:28","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5739"},"modified":"2021-08-06T03:22:28","modified_gmt":"2021-08-05T19:22:28","slug":"sources-of-common-compounds-25711-30-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5739","title":{"rendered":"Sources of common compounds: 25711-30-2"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25711-30-2, name is 1,5-Dimethyl-1H-pyrazole-4-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1,5-Dimethyl-1H-pyrazole-4-carbaldehyde<\/a><\/p>\n

A mixture of 1 ,5-dimethyl-1 H-pyrazole-4-carbaldehyde (Zhurnal Obshchei Khimii 1980, 50, 2370-5, 2.0 g, 16,1 mmol), terf-butylsulfinamide (2.05 g, 16.9 mmol), and Ti(OEt)4 (6.76 ml, 32.2 mmol) in THF (32 ml) was heated under reflux for 18 h under nitrogen. After being cooled to rt, the mixture was poured into brine (32 ml) with stirring. The resulting suspension was filtered through a plug of Celite, and the filter cake was washed with EtOAc. The filtrate was transferred to a separation funnel, and organic layer was washed with brine. Then the aqueous layer was washed with EtOAc and the combined organic extracts were dried over Na2SO4, and concentrated in vacuo. The crude material was purified by silica gel chromatography (CH2CI2:MeOH=50:1-30:1 ) to give the desired product as a white solid (3.55 g, 97% yield). 1H NMR (300 MHz, CDCI3) delta 1.23 (9H, s), 2.52 (3H, s), 3.83 (3H, s), 7.81 (1H, s), 8.49 (1H, s). MS (ESI) m\/z 228 (M + H)+<\/p>\n

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 25711-30-2.<\/p>\n

Reference:
Patent; PFIZER JAPAN INC.; PFIZER INC.; RENOVIS, INC.; WO2008\/59370; (2008); A2;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 25711-30-2.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[260,131],"tags":[126],"class_list":["post-5739","post","type-post","status-publish","format-standard","hentry","category-25711-30-2","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSources of common compounds:<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25711-30-2, name is 1,5-Dimethyl-1H-pyrazole-4-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1,5-Dimethyl-1H-pyrazole-4-carbaldehyde\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=5739\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sources of common compounds:\" \/>\n<meta property=\"og:description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25711-30-2, name is 1,5-Dimethyl-1H-pyrazole-4-carbaldehyde, This compound has unique chemical properties. 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