{"id":5724,"date":"2021-08-05T03:16:12","date_gmt":"2021-08-04T19:16:12","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5724"},"modified":"2021-08-05T03:16:12","modified_gmt":"2021-08-04T19:16:12","slug":"continuously-updated-synthesis-method-about-3-trifluoromethyl-1h-pyrazol-5-amine-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5724","title":{"rendered":"Continuously updated synthesis method about 3-(Trifluoromethyl)-1H-pyrazol-5-amine"},"content":{"rendered":"

Related Products of 852443-61-9<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 852443-61-9 as follows.<\/p>\n

A solution of 3-(trifluorometliyl)-lH-pyrazol-5-amine (1 equic.) in 1,4-dioxane (0.2 M) was treated with 1,3-dibromopropane (1.2 equiv.) and triethylamine (5 equiv.) at 0 C and the reaction mixture was heated to 100 C for 12 h. After completion, reaction mixture was cooled to room temperature, filtered under reduced pressure and concentrated to afford crude product. The crude product was purified by flash chromatography to afford the product. 1H NMR (400 MHz, DMSO-d6): 12.25 (brs, IH), 6.40 (s, IH), 5.52 (s, IH), 4.03-4.00 (t, 2H), 3.58 (s, IH), 3.18-3.15 (m, 2H), 2.05-1.97 (m, 2H). LC-MS: MS m\/z 192 [M+H]+.<\/p>\n

According to the analysis of related databases, 852443-61-9, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH; ALAM, Jenefer; HO, Soo Yei; WANG, Wei Ling; DURAISWAMY, Athisayamani Jeyaraj; WO2015\/94119; (2015); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 852443-61-9, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[452,131],"tags":[126],"class_list":["post-5724","post","type-post","status-publish","format-standard","hentry","category-852443-61-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nContinuously updated synthesis method about<\/title>\n<meta name=\"description\" content=\"Related Products of 852443-61-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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