{"id":5723,"date":"2021-08-05T03:16:12","date_gmt":"2021-08-04T19:16:12","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5723"},"modified":"2021-08-05T03:16:12","modified_gmt":"2021-08-04T19:16:12","slug":"research-on-new-synthetic-routes-about-153912-60-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5723","title":{"rendered":"Research on new synthetic routes about 153912-60-8"},"content":{"rendered":"

Reference of 153912-60-8<\/a>, These common heterocyclic compound, 153912-60-8, name is 1,5-Dimethyl-1H-pyrazol-3-yl-methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

[5-Cyano-7-(1,5-dimethyl-1H-pyrazol-3-ylmethoxy)-8-methyl-1-propyl-1,3,4,9-tetrahydro pyrano[3,4-b]indol-1-yl]-acetic acid To a solution of 5-cyano-7-hydroxy-8-methyl-1-propyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol-1-yl)-acetic acid methyl ester (50 mg, 0.15 mmoles) in DCM (1 mL) was added (1,5-dimethyl-1H-pyrazol-3-yl)-methanol (20 mg, 0.17 mmoles) and triphenylphosphine (95 mg, 0.37 mmol). To this was added 1,1′-(azodicarbonyl)dipiperidine (ADDP, 92 mg, 0.37 mmoles). The reaction was stirred for 1.5 hours, diluted with EtOAc and washed twice with H2O and brine. The EtOAc layer was dried (MgSO4) and concentrated. Flash chromatography on SiO2 eluding with 1:1 hexane\/EtOAc yielded 53 mg (80%) of a yellow oil that crystallized upon standing.<\/p>\n

Statistics shows that 1,5-Dimethyl-1H-pyrazol-3-yl-methanol is playing an increasingly important role. we look forward to future research findings about 153912-60-8.<\/p>\n

Reference:
Patent; Condon, Stephen M.; Jackson, Randy William; Laporte, Matthew G.; Burns, Christopher J.; Herbertz, Torsten; Gaboury, Janet A.; US2007\/219212; (2007); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

Statistics shows that 1,5-Dimethyl-1H-pyrazol-3-yl-methanol is playing an increasingly important role. we look forward to future research findings about 153912-60-8.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[579,131],"tags":[126],"class_list":["post-5723","post","type-post","status-publish","format-standard","hentry","category-153912-60-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nResearch on new synthetic routes about<\/title>\n<meta name=\"description\" content=\"Reference of 153912-60-8, These common heterocyclic compound, 153912-60-8, name is 1,5-Dimethyl-1H-pyrazol-3-yl-methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=5723\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research on new synthetic routes about\" \/>\n<meta property=\"og:description\" content=\"Reference of 153912-60-8, These common heterocyclic compound, 153912-60-8, name is 1,5-Dimethyl-1H-pyrazol-3-yl-methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=5723\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-08-04T19:16:12+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=5723\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=5723\",\"name\":\"Research on new synthetic routes about\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-08-04T19:16:12+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Reference of 153912-60-8, These common heterocyclic compound, 153912-60-8, name is 1,5-Dimethyl-1H-pyrazol-3-yl-methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=5723#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=5723\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=5723#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research on new synthetic routes about 153912-60-8\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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